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Zntppea As A Potential Photosensitizer In Photodynamic Therapy, Marly Welborn, Joseph E. Bradshaw
Zntppea As A Potential Photosensitizer In Photodynamic Therapy, Marly Welborn, Joseph E. Bradshaw
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Photodynamic therapy (PDT) is an emerging treatment that is used against certain types of cancer and other diseases. It functions using a photosensitizer in the presence of light that contributes to cell death in the desired tissues. This research centered on the development of a novel water-soluble porphyrin that could be utilized as a photosensitizer. Using ethanolamine the resulting compound, ZnTPP-EA, was created. Purification and characterization was carried out. The ZnTPP-EA was tested on the A549 lung cancer cell line using an MTT assay under light and dark conditions to assess the compound's effectiveness as a photosensitizer for PDT.