Medicine and Health Sciences Commons^™

A Mathematical Model For Cell Cycle-Specific Cancer Virotherapy, Joanna R. Wares, Joseph J. Crivelli, Juraj Földes, Peter S. Kim

Department of Math & Statistics Faculty Publications

Oncolytic viruses preferentially infect and replicate in cancerous cells, leading to elimination of tumour populations, while sparing most healthy cells. Here, we study the cell cycle-specific activity of viruses such as vesicular stomatitis virus (VSV). In spite of its capacity as a robust cytolytic agent,VSVcannot effectively attack certain tumour cell types during the quiescent, or resting, phase of the cell cycle. In an effort to understand the interplay between the time course of the cell cycle and the specificity of VSV, we develop a mathematical model for cycle-specific virus therapeutics. We incorporate the minimum biologically required time spent in the …