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Full-Text Articles in Medicine and Health Sciences
Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins
Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins
Honors Program Theses
By the time a cancer metastasizes it has reached its most deadly stage. It therefore is essential that the underpinning mechanisms promoting metastasis are understood. Phosphatases of regenerating liver (PRL) have been repeatedly connected to cancer metastasis when overexpressed. However, little is yet known about the normal PRL function and biological pathways let alone the PRL pathway promoting metastasis. The current study explores the relationship between PRL-1 and two other genes, ROK and Rac,that have also been implicated in cell migration and metastasis. Increased PRL-1 function in conjunction with increased or decreased Rac function was forced to the dorsal half …
Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn
Summer Research
The human body exhibits a spectacular collection of cells, integrated with seemingly infinite communication techniques and control mechanisms. Cancer’s disastrous influence on this complex system proves difficult to map. The shotgun clinical trial testing of human cancers has provided a feast of proteins suspected of encouraging cancerous cell behavior. One, Phosphatase of Regenerating Liver protein-1 (PRL-1), has been found to encourage cancerous growth while localizing in a variety of subcellular locations within metastasizing human tumor cells. However, PRL-1 has also been found to act as a tumor suppressor while localizing to the cell membrane in mammalian and insect models. In …
Single Cell Wound Healing In Drosophila Melanogaster Embryos, John Rosasco
Single Cell Wound Healing In Drosophila Melanogaster Embryos, John Rosasco
Summer Research
The role of contractile actin and myosin filaments filaments and the links they form with other proteins are vitally important to single cell wound healing, Which occurs in synctial Drosophila embryos as well as in vertebrates. Previous work by Wayne Rickoll has concentrated on determining the orientations of actin during wound healing during dorsal closure in Drosophila, a morphogenetic process in which epidermal cells extend to cover the embryonic gut during development. Transmission electron microscope analysis of cells undergoing dorsal closure revealed that actin is oriented parallel and perpendicular to the leading edge of the wound. Based on this …