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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Novel Developmental Biology-Based Protocol Of Embryonic Stem Cell Differentiation To Morphologically Sound And Functional Yet Immature Hepatocytes, Terence Bukong, Tracie Lo, Gyongyi Szabo, Angela Dolganiuc
Novel Developmental Biology-Based Protocol Of Embryonic Stem Cell Differentiation To Morphologically Sound And Functional Yet Immature Hepatocytes, Terence Bukong, Tracie Lo, Gyongyi Szabo, Angela Dolganiuc
Gyongyi Szabo
BACKGROUND/AIMS: Liver diseases are common in the United States and often require liver transplantation; however, donated organs are limited and thus alternative sources for liver cells are in high demand. Embryonic stem cells (ESC) can provide a continuous and readily available source of liver cells. ESC differentiation to liver cells is yet to be fully understood and comprehensive differentiation protocols are yet to be defined. Here, we aimed to achieve human (h)ESC differentiation into mature hepatocytes using defined recombinant differentiation factors and metabolites. METHODS: Embryonic stem cell H1 line was sub-cultured on feeder layer. We induced hESCs into endodermal differentiation …
Library Impact Statement For Bps 555 Protein Molecular Modeling, Michael Vocino
Library Impact Statement For Bps 555 Protein Molecular Modeling, Michael Vocino
michael c vocino
Library Impact Statement for BPS 555 Protein Molecular Modeling. No new resources were required to support this course.
Multifetal Pregnancy May Increase The Risk For Severe Maternal And Neonatal Vitamin D Deficiency, Benjamin U. Nwosu, Leslie A. Soyka, Amanda Angelescu, Olga T. Hardy, Mary M. Lee
Multifetal Pregnancy May Increase The Risk For Severe Maternal And Neonatal Vitamin D Deficiency, Benjamin U. Nwosu, Leslie A. Soyka, Amanda Angelescu, Olga T. Hardy, Mary M. Lee
Benjamin U. Nwosu
Vitamin D deficiency is prevalent in pregnant women. This deficiency could be exaggerated in multifetal pregnancies by the increased demand on maternal stores of vitamin D. We present 2 cases in which hypocalcemia and secondary hyperparathyroidism occurred in 2 sets of twins from mothers with vitamin D deficiency. The first mother had gastric bypass surgery and Crohn disease. The second mother had no apparent cause of vitamin D deficiency. Both women had iron deficiency anemia and lived in Northeastern United States. We speculate that in twins, the demand for 25-hydroxyvitamin D by 2 fetuses could deplete the 25-hydroxyvitamin D stores …