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Full-Text Articles in Medicine and Health Sciences
Reaction-Diffusion Models Of Cancer Dispersion, Kim Yvette Ward
Reaction-Diffusion Models Of Cancer Dispersion, Kim Yvette Ward
Mathematics & Statistics Theses & Dissertations
The phenomenological modeling of the spatial distribution and temporal evolution of one-dimensional models of cancer dispersion are studied. The models discussed pertain primarily to the transition of a tumor from an initial neoplasm to the dormant avascular state, i.e. just prior to the vascular state, whenever that may occur. Initiating the study is the mathematical analysis of a reaction-diffusion model describing the interaction between cancer cells, normal cells and growth inhibitor. The model leads to several predictions, some of which are supported by experimental data and clinical observations $\lbrack25\rbrack$. We will examine the effects of additional terms on these characteristics. …
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
Theses and Dissertations in Biomedical Sciences
The targeting of proven anticancer drugs specifically to cancer cells would provide a unique opportunity to restrict neoplasms without damaging the cancer patient. The present research utilizes the phenomenon of illicit transport, i.e. the coupling of normally impermeant metabolites to permeant metabolites, in targeting the drug melphalan to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was used as a control treatment. In addition, both melphalan and beta-alanyl-melphalan were utilized in in vivo chemotherapeutic …