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Full-Text Articles in Medicine and Health Sciences
Actinomycin D And Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green
Actinomycin D And Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green
USF Tampa Graduate Theses and Dissertations
The failure of lung cancer treatments has been attributed partly to the development of drug resistance, however the underlying cellular and molecular mechanisms are poorly understood. It has been suggested that a very small group of specific cells within the heterogeneous tumors, cancer initiating stem cells (CSC), develop resistance to treatment, survive and later initiate the growth of new tumors. Due to their pivotal role in maintenance and relapse of tumors following the acquisition of drug resistance, we reasoned that novel drugs targeting cancer cells and CSC might provide the most effective treatments, if not a cure. To this end, …
Circadian Regulation Of Temozolomide Sensitivity In Glioblastoma, Emily A. Slat
Circadian Regulation Of Temozolomide Sensitivity In Glioblastoma, Emily A. Slat
Arts & Sciences Electronic Theses and Dissertations
The safety and efficacy of multiple cancer chemotherapeutics can vary as a function of when during the day they are delivered. This study aimed to improve the treatment of glioblastoma multiforme (GBM), the most common brain cancer, by testing the efficacy of the DNA alkylator Temozolomide (TMZ) on GBM in vitro and in vivo as a function of time of day. We found cell-intrinsic, daily rhythms in susceptibility of GBM tumor cells (mouse astrocytes deficient in NF1 and p53 signaling) to TMZ in vitro. The greatest TMZ-induced DNA damage response, activation of apoptosis and growth inhibition, occurred near the peak …