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Full-Text Articles in Medicine and Health Sciences
Developing Zntpp-4ab As A Potential Photodynamic Therapy Agent, Kennedy Johnson
Developing Zntpp-4ab As A Potential Photodynamic Therapy Agent, Kennedy Johnson
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Photodynamic therapy is a fairly new technique used in cancer treatment involving the use of a photosensitizer and light exposure to kill malignant cells. In this research, the use of ZnTPP-4AB as a photosensitizer and red light as a source of radiant light energy was explored in terms of cytotoxicity in the A549 lung cancer cell line. ZnTPP-4AB was synthesized by replacing the carbonyl functional groups on the ZnTPPC porphyrin with 4-amino-1-butanol. Following synthesis, the new porphyrin was purified through the use of Sephadex LH-20 and G-50 in column chromatography in order to remove impurities. To confirm the identity and …
The Development Of A New Water-Soluble Zinc Porphyrin, Zntpp-2mp, As A Photodynamic Therapy Agent, Emily Payne
The Development Of A New Water-Soluble Zinc Porphyrin, Zntpp-2mp, As A Photodynamic Therapy Agent, Emily Payne
Scholars Day Conference
Photodynamic therapy is a new technique used in cancer treatment involving the use of a photosensitizer and light exposure to kill malignant cells. This research tested the use of ZnTPP-2MP as a photosensitizer using white light as a source of possible treatment of the A549 cancer cell line, with preliminary testing on MYC-22 and other G- quadruplex DNA samples. ZnTPP-2MP was synthesized by the reaction of the porphyrin, ZnTPPC, with 2-amino-2- methyl-1-propanol. Following synthesis, the new porphyrin was purified by column chromatography using Sephadex LH-20 and G-50. To confirm the identity and structure of the product, ZnTPP-2MP was analyzed through …
Using Oncodb's Oncovirus Analysis For Hbv-Related Hcc, Anna Claire Newman
Using Oncodb's Oncovirus Analysis For Hbv-Related Hcc, Anna Claire Newman
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Since one of the known causes of cancer is virus infection causing changes in gene regulation, being able to compare the expression and methylation of regular tumors and virus-related tumors could provide much needed information into virus induced cancer such as HBV-related HCC. OncoDB's oncovirus analysis capabilities can provide information and research opportunities that past research has not had.
Zntppea As A Potential Photosensitizer In Photodynamic Therapy, Marly Welborn, Joseph E. Bradshaw
Zntppea As A Potential Photosensitizer In Photodynamic Therapy, Marly Welborn, Joseph E. Bradshaw
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Photodynamic therapy (PDT) is an emerging treatment that is used against certain types of cancer and other diseases. It functions using a photosensitizer in the presence of light that contributes to cell death in the desired tissues. This research centered on the development of a novel water-soluble porphyrin that could be utilized as a photosensitizer. Using ethanolamine the resulting compound, ZnTPP-EA, was created. Purification and characterization was carried out. The ZnTPP-EA was tested on the A549 lung cancer cell line using an MTT assay under light and dark conditions to assess the compound's effectiveness as a photosensitizer for PDT.