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Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins

Honors Program Theses

By the time a cancer metastasizes it has reached its most deadly stage. It therefore is essential that the underpinning mechanisms promoting metastasis are understood. Phosphatases of regenerating liver (PRL) have been repeatedly connected to cancer metastasis when overexpressed. However, little is yet known about the normal PRL function and biological pathways let alone the PRL pathway promoting metastasis. The current study explores the relationship between PRL-1 and two other genes, ROK and Rac,that have also been implicated in cell migration and metastasis. Increased PRL-1 function in conjunction with increased or decreased Rac function was forced to the dorsal half …