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Full-Text Articles in Medicine and Health Sciences
Membrane Channel Gene Expression In Human Costal And Articular Chondrocytes, A. Asmar, R. Barrett-Jolley, A. Werner, R. Kelly Jr., M. Stacey
Membrane Channel Gene Expression In Human Costal And Articular Chondrocytes, A. Asmar, R. Barrett-Jolley, A. Werner, R. Kelly Jr., M. Stacey
Bioelectrics Publications
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their function is the ability to respond to mechanical loads with changes of metabolic activity. This mechanotransduction property is, in part, mediated through the activity of a range of expressed transmembrane channels; ion channels, gap junction proteins, and porins. Appropriate expression of ion channels has been shown essential for production of extracellular matrix and differential expression of transmembrane channels is correlated to musculoskeletal diseases such as osteoarthritis and Albers-Sch€onberg. In this study we analyzed the consistency of gene expression between channelomes of chondrocytes from human …
Atomic Force Microscopy Characterization Of Collagen ‘Nanostraws’ In Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., A. Beskok
Atomic Force Microscopy Characterization Of Collagen ‘Nanostraws’ In Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., A. Beskok
Bioelectrics Publications
Costal cartilage, a type of hyaline cartilage that bridges the bony ribs and sternum, is relatively understudied compared to the load bearing cartilages. Deformities of costal cartilage can result in deformation of the chest wall, where the sternum is largely pushed toward or away from the spine, pectus excavatum and pectus carinatum, respectively, with each condition having significant clinical impact. In the absence of extensive literature describing morphological features of costal cartilage, we characterized a sample from the costal margin immunohistologically and through atomic force microscopy. We had previously observed the presence of collagen ‘nanostraws’ running the length of costal …
Decorin Expression, Straw-Like Structure, And Differentiation Of Human Costal Cartilage, Michael W. Stacey, Janna Grubb, Anthony Asmar, Julie Pryor, Hani Elsayed-Ali, Ali Beskok, Diganta Dutta, Annie Fecteau, Alice Werner, Dennis A. Darby, Robert Kelly
Decorin Expression, Straw-Like Structure, And Differentiation Of Human Costal Cartilage, Michael W. Stacey, Janna Grubb, Anthony Asmar, Julie Pryor, Hani Elsayed-Ali, Ali Beskok, Diganta Dutta, Annie Fecteau, Alice Werner, Dennis A. Darby, Robert Kelly
Bioelectrics Publications
Costal cartilage is much understudied compared with the load-bearing cartilages. Abnormally grown costal cartilages are associated with the inherited chest wall deformities pectus excavatum and pectus carinatum resulting in sunken and pigeon chests, respectively. A lack of understanding of the ultrastructural and molecular biology of costal cartilage is a major confounder in predicting causes and outcomes of these disorders. This study analyzed the structure of marginal human costal cartilage (ribs 6-10) through scanning electron and atomic force microscopes and identified the presence of straw-like structures running longitudinally. We also demonstrated that chondrocytes tend to occur singly or as doublets and …