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Articles 1 - 30 of 44
Full-Text Articles in Medicine and Health Sciences
Measuring Science Teachers' Emotional Experiences With Evolution Using Real World Scenarios, William Lee Romine, Rutuja Mahajan, Amber Todd
Measuring Science Teachers' Emotional Experiences With Evolution Using Real World Scenarios, William Lee Romine, Rutuja Mahajan, Amber Todd
Biological Sciences Faculty Publications
Low acceptance of evolution remains an obstacle to quality biology instruction. We develop and utilize a novel assessment which measures emotional experience in light of real-world evolution education scenarios. We presented 296 science teachers 4 pro-evolution and 8 anti-evolution scenarios and asked them to rate their levels of joy, anger, sadness, fear, disgust, shame, and guilt elicited by that scenario on an ordinal 5-point scale. We used exploratory factor analysis to extract the most important dimensions in the teachers’ responses, Rasch analysis to explore the validity of the extracted subscales, and stepwise regression to find the most important factors driving …
A Dystrophin Exon‐52 Deleted Miniature Pig Model Of Duchenne Muscular Dystrophy And Evaluation Of Exon Skipping, Yusuke Echigoya, Nhu Trieu, William Duddy, Hong M. Moulton, Haifang Yin, Terence A. Partridge, Eric P. Hoffman, Joe N. Kornegay, Frank A. Rohret, Christopher S. Rogers, Toshifumi Yokota
A Dystrophin Exon‐52 Deleted Miniature Pig Model Of Duchenne Muscular Dystrophy And Evaluation Of Exon Skipping, Yusuke Echigoya, Nhu Trieu, William Duddy, Hong M. Moulton, Haifang Yin, Terence A. Partridge, Eric P. Hoffman, Joe N. Kornegay, Frank A. Rohret, Christopher S. Rogers, Toshifumi Yokota
Genomics and Precision Medicine Faculty Publications
No abstract provided.
Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie
Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie
Publications and Research
Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning , to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) …
An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues, Clayton Neuenschwander, Katrina Wu, Teresa F. Degolier
An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues, Clayton Neuenschwander, Katrina Wu, Teresa F. Degolier
Biological Sciences Faculty Publications
Introduction: Alternative solutions in the form of herbal remedies meant to ease or expedite the process of labor have often been pursued and administered but have seldom been quantitatively tested for efficacy. Published research has shown some validation for some commonly used herbs such as blue cohosh (Caulophyllum thalictroides), red raspberry (Rubus idaeus), castor bean (Ricinus communis) and evening primrose (Oenothera biennis) on isolated mouse uterine strips. Methods: This study tested an array of herbs used by midwives in a labor induction tincture, which included black cohosh (Actaea racemosa), cramp bark (Viburnum opulus), partridgeberry (Mitchella repens), and motherwort (Leonurus cardiaca). …
Zebrafish Paralogs Brd2a And Brd2b Are Needed For Proper Circulatory, Excretory And Central Nervous System Formation And Act As Genetic Antagonists During Development, Gregory L Branigan, Kelly S Olsen, Isabella Burda, Matthew W Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D D'Antonio, Ian E Briggs, Angela J Dibenedetto
Zebrafish Paralogs Brd2a And Brd2b Are Needed For Proper Circulatory, Excretory And Central Nervous System Formation And Act As Genetic Antagonists During Development, Gregory L Branigan, Kelly S Olsen, Isabella Burda, Matthew W Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D D'Antonio, Ian E Briggs, Angela J Dibenedetto
Department of Biochemistry and Molecular Biology Faculty Papers
Brd2 belongs to the BET family of epigenetic transcriptional co-regulators that act as adaptor-scaffolds for the assembly of chromatin-modifying complexes and other factors at target gene promoters. Brd2 is a protooncogene and candidate gene for juvenile myoclonic epilepsy in humans, a homeobox gene regulator in Drosophila, and a maternal-zygotic factor and cell death modulator that is necessary for normal development of the vertebrate central nervous system (CNS). As two copies of Brd2 exist in zebrafish, we use antisense morpholino knockdown to probe the role of paralog Brd2b, as a comparative study to Brd2a, the ortholog of human Brd2. A deficiency …
Influence Of The Covid-19 Pandemic On Amphibian Road Mortality, Gregory Leclair, Matthew H. Chatfield, Zachary Wood, Jeffrey Parmelee, Cheryle A. Frederick
Influence Of The Covid-19 Pandemic On Amphibian Road Mortality, Gregory Leclair, Matthew H. Chatfield, Zachary Wood, Jeffrey Parmelee, Cheryle A. Frederick
Teaching, Learning & Research Documents
The COVID-19 pandemic and its related human activity shutdowns provide unique opportunities for biodiversity monitoring through what has been termed the “anthropause” or the “great human confinement experiment.” The pandemic caused immense disruption to human activity in the northeastern United States in the spring of 2020, with notable reductions in traffic levels. These shutdowns coincided with the seasonal migration of adult amphibians, which are typically subject to intense vehicle-impact mortality. Using data collected as part of an annual community science monitoring program in Maine from 2018 to 2021, we examined how amphibian mortality probabilities responded to reductions in traffic during …
Mara Repression Of Virulence Gene Hila In Salmonella, Alexandra King, Lauren Daugherty, Lon Chubiz Phd
Mara Repression Of Virulence Gene Hila In Salmonella, Alexandra King, Lauren Daugherty, Lon Chubiz Phd
Undergraduate Research Symposium
Salmonella is a bacteria most commonly known for causing the eponymous food-related illness. Due to their rapid reproduction rate and their ability to be propogated and maintained in a lab setting, they are commonly used in lab studies so that we can better understand how Salmonella causes disease in organisms that are more difficult to study. One area of interest is analyzing how Salmonella controls expression of the mechanisms that actually cause disease, called virulence traits, in response to the environment. In this study, antibiotic stress was used to analyze virulence gene expression. MarA is a gene that regulates ampicillin …
Comparative Analysis Of Longevity And Stress Resiliency Benefits Of Supplementation With High-Antioxidative Capacity Juices In Organisms That Are Representative Of Humans, Meghan Long
Honors Scholar Theses
Neurodegenerative disease presents itself in a complex array of illnesses that is increasingly affecting the geriatric population. There has not been research on a common cause since there are a culmination of reasons that are probable ranging from genetic to environmental factors. Antioxidants have been known to prevent and protect against the damage that is otherwise caused by reactive oxygen species (ROS). Thus, high-capacity antioxidant juices supplemented into the diet of animal models such as Caenorhabditis elegans, Drosophila melanogaster, rats, and humans will allow for the study of the possible benefits.
Although a conclusion and common causation on the usage …
Increasing Public Health Mosquito Surveillance In Hidalgo County, Texas To Monitor Vector And Arboviral Presence, Clarissa D. Guerrero, Steven Hinojosa, Diana Vanegas, Niko Tapangan, Matthew Guajardo, Sara Alaniz, Narda Cano, Christopher Vitek, John Thomas, Valerie Hernandez, Juan Garcia Jr.
Increasing Public Health Mosquito Surveillance In Hidalgo County, Texas To Monitor Vector And Arboviral Presence, Clarissa D. Guerrero, Steven Hinojosa, Diana Vanegas, Niko Tapangan, Matthew Guajardo, Sara Alaniz, Narda Cano, Christopher Vitek, John Thomas, Valerie Hernandez, Juan Garcia Jr.
Biology Faculty Publications and Presentations
From 2016 to 2018, Hidalgo County observed the emergence of Zika virus (ZIKV) infections along with sporadic cases of Dengue virus (DENV) and West Nile virus (WNV). Due to the emergence of ZIKV and the historical presence of other mosquito-borne illnesses, Hidalgo County obtained funding to enhance mosquito surveillance and educate residents on arboviruses and travel risks. During this time period, Hidalgo County mosquito surveillance efforts increased by 1.275%. This increase resulted in >8000 mosquitoes collected, and 28 mosquito species identified. Aedes aegypti, Ae albopictus and Culex quinquefasciatus made up approximately two-thirds of the mosquitoes collected in 2018 (4122/6171). Spatiotemporal …
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Biological, Geological, and Environmental Faculty Publications
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere …
Dimeric Allostery Mechanism Of The Plant Circadian Clock Photoreceptor Zeitlupe, Francesco Trozzi, Feng Wang, Gennady M. Verkhivker, Brian D. Zoltowski, Peng Tao
Dimeric Allostery Mechanism Of The Plant Circadian Clock Photoreceptor Zeitlupe, Francesco Trozzi, Feng Wang, Gennady M. Verkhivker, Brian D. Zoltowski, Peng Tao
Mathematics, Physics, and Computer Science Faculty Articles and Research
In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock. Recent structural and biochemical studies of ZTL indicate that the protein diverges from other members of the LOV superfamily in its allosteric mechanism, and that the divergent allosteric mechanism hinges upon conservation of two signaling residues G46 and V48 that alter dynamic motions of a Gln residue implicated in signal transduction in all LOV proteins. Here, we delineate the allosteric mechanism of ZTL via an integrated computational approach that employs atomistic simulations of wild type and …
A Kinetic Model For Blood Biomarker Levels After Mild Traumatic Brain Injury, Sima Azizi, Daniel B. Hier, Blaine Allen, Tayo Obafemi-Ajayi, Gayla R. Olbricht, Matthew S. Thimgan, Donald C. Wunsch
A Kinetic Model For Blood Biomarker Levels After Mild Traumatic Brain Injury, Sima Azizi, Daniel B. Hier, Blaine Allen, Tayo Obafemi-Ajayi, Gayla R. Olbricht, Matthew S. Thimgan, Donald C. Wunsch
Mathematics and Statistics Faculty Research & Creative Works
Traumatic brain injury (TBI) imposes a significant economic and social burden. The diagnosis and prognosis of mild TBI, also called concussion, is challenging. Concussions are common among contact sport athletes. After a blow to the head, it is often difficult to determine who has had a concussion, who should be withheld from play, if a concussed athlete is ready to return to the field, and which concussed athlete will develop a post-concussion syndrome. Biomarkers can be detected in the cerebrospinal fluid and blood after traumatic brain injury and their levels may have prognostic value. Despite significant investigation, questions remain as …
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Biological, Geological, and Environmental Faculty Publications
Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. Many subtelomeric genes are important for responding to environmental cues, and subtelomeric instability can facilitate organismal adaptation to extracellular changes, which is a common theme in a number of microbial pathogens. In this review, I will focus on the delicate and important balance between stability and plasticity at telomeres and subtelomeres of a kinetoplastid parasite, Trypanosoma brucei, which causes human African trypanosomiasis and undergoes antigenic variation to evade the …
Genetically Encoded Multivalent Liquid Glycan Array Displayed On M13 Bacteriophage, Amira Khalil, Mirat Sojitra, Jasmine Maghera, Emily Rodrigues, Eric J. Carpenter, Shaurya Seth, Daniel Ferrer Vinals, Todd L. Lowary
Genetically Encoded Multivalent Liquid Glycan Array Displayed On M13 Bacteriophage, Amira Khalil, Mirat Sojitra, Jasmine Maghera, Emily Rodrigues, Eric J. Carpenter, Shaurya Seth, Daniel Ferrer Vinals, Todd L. Lowary
Pharmacy
The central dogma of biology does not allow for the study of glycans using DNA sequencing. We report a liquid glycan array (LiGA) platform comprising a library of DNA ‘barcoded’ M13 virions that display 30–1,500 copies of glycans per phage. A LiGA is synthesized by acylation of the phage pVIII protein with a dibenzocyclooctyne, followed by ligation of azido-modified glycans. Pulldown of the LiGA with lectins followed by deep sequencing of the barcodes in the bound phage decodes the optimal structure and density of the recognized glycans. The LiGA is target agnostic and can measure the glycan-binding profile of lectins, …
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Faculty Publications and Presentations
New and reemerging diseases are terrifying and concerning problems. Not only do they carry a financial and emotional toll, but they account for significant numbers of death. Emerging diseases are usually zoonotic and highly virulent in nature. These are pathogenic and parasitic diseases of high consequence and impact. Why would a good Creator allow these new diseases? Why do new diseases keep popping up? Mutation and displacement of original types of microbes account for many new diseases; however, the answer is more complex than just these two factors. Zoonoses are the most common type of infection, specifically from viral pathogens, …
Public Discussion Of Anthrax On Twitter: Using Machine Learning To Identify Relevant Topics And Events, Michele Miller, William Lee Romine, Terry L. Oroszi
Public Discussion Of Anthrax On Twitter: Using Machine Learning To Identify Relevant Topics And Events, Michele Miller, William Lee Romine, Terry L. Oroszi
Biological Sciences Faculty Publications
Background: Social media allows researchers to study opinions and reactions to events in real time. One area needing more study is anthrax-related events. A computational framework that utilizes machine learning techniques was created to collect tweets discussing anthrax, further categorize them as relevant by the month of data collection, and detect discussions on anthrax-related events. Objective: The objective of this study was to detect discussions on anthrax-related events and to determine the relevance of thetweets and topics of discussion over 12 months of data collection. Methods: This is an infoveillance study, using tweets in English containing the keyword “Anthrax” and …
Deacylated Trna Accumulation Is A Trigger For Bacterial Antibiotic Persistence Independent Of The Stringent Response, Whitney N. Wood, Kyle Mohler, Jesse Rinehart, Michael Ibba
Deacylated Trna Accumulation Is A Trigger For Bacterial Antibiotic Persistence Independent Of The Stringent Response, Whitney N. Wood, Kyle Mohler, Jesse Rinehart, Michael Ibba
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Bacterial antibiotic persistence occurs when bacteria are treated with an antibiotic and the majority of the population rapidly dies off, but a small subpopulation enters into a dormant, persistent state and evades death. Diverse pathways leading to nucleoside triphosphate (NTP) depletion and restricted translation have been implicated in persistence, suggesting alternative redundant routes may exist to initiate persister formation. To investigate the molecular mechanism of one such pathway, functional variants of an essential component of translation (phenylalanyltRNA synthetase [PheRS]) were used to study the effects of quality control on antibiotic persistence. Upon amino acid limitation, elevated PheRS quality control led …
Evaluating The Effects Of Physical Activity On The Cognitive Functions And Motor Skills Of The Special Needs Population And Testing A Different Teaching Style To Maximize The Efficiency Of Special Needs Programs, Oren Nedjar
BIO4960: Practicum in Biology I
This study aimed to analyze the effects of physical activities on the motor and cognitive functions of participants with special needs and compare these results with a similar program but organized online because of the health precautions that have been applied due to the COVID-19 pandemic. An intervention consisting of sending an educational brochure aiming to increase high school volunteers' health literacy was then tested and results showed that it improved participants' health outcomes and also could increase the program's effectiveness in the long term.
Infectious Disease Transmission By Arline Travel, Daniele Provenzano, Sofy Barocio
Infectious Disease Transmission By Arline Travel, Daniele Provenzano, Sofy Barocio
Biology Faculty Publications and Presentations
Improvements in aviation technology have led to considerable growth of domestic and international flights worldwide especially during the past four decades. Commercial flights have increased the movement of and have connected people from virtually all corners of the globe since the end of World War II to exceed 3 billion passengers a year since 2013: a sizable proportion of the global human population. Flight times have decreased considerably from the onset of commercial aviation and the range of airliners has extended substantially. A passenger harboring an infectious agent embarking a flight on one continent can be deplaning on another continent …
Mathematical Models Of Covid-19, Kate Faria
Mathematical Models Of Covid-19, Kate Faria
Honors Program Theses and Projects
For more than a year, the COVID-19 pandemic has been a major public health issue, affecting the lives of most people around the world. With both people’s health and the economy at great risks, governments rushed to control the spread of the virus. Containment measures were heavily enforced worldwide until a vaccine was developed and distributed. Although researchers today know more about the characteristics of the virus, a lot of work still needs to be done in order to completely remove the disease from the population. However, this is true for most of the infectious diseases in existence, including Influenza, …
The Interconnectivity Of Parkinson's Disease And Type Two Diabetes Mellitus, Erica Olfson
The Interconnectivity Of Parkinson's Disease And Type Two Diabetes Mellitus, Erica Olfson
Honors Scholars Collaborative Projects
This thesis is about the biochemical connection between Parkinson's disease and Type II Diabetes Mellitus.
The Giant Axolotl Genome Uncovers The Evolution, Scaling, And Transcriptional Control Of Complex Gene Loci, Siegfried Schloissnig, Akane Kawaguchi, Sergej Nowoshilow, Francisco Falcon, Leo Otsuki, Pietro Tardivo, Nataliya Timoshevskaya, Melissa C. Keinath, Jeramiah J. Smith, S. Randal Voss, Elly M. Tanaka
The Giant Axolotl Genome Uncovers The Evolution, Scaling, And Transcriptional Control Of Complex Gene Loci, Siegfried Schloissnig, Akane Kawaguchi, Sergej Nowoshilow, Francisco Falcon, Leo Otsuki, Pietro Tardivo, Nataliya Timoshevskaya, Melissa C. Keinath, Jeramiah J. Smith, S. Randal Voss, Elly M. Tanaka
Biology Faculty Publications
Vertebrates harbor recognizably orthologous gene complements but vary 100-fold in genome size. How chromosomal organization scales with genome expansion is unclear, and how acute changes in gene regulation, as during axolotl limb regeneration, occur in the context of a vast genome has remained a riddle. Here, we describe the chromosome-scale assembly of the giant, 32 Gb axolotl genome. Hi-C contact data revealed the scaling properties of interphase and mitotic chromosome organization. Analysis of the assembly yielded understanding of the evolution of large, syntenic multigene clusters, including the Major Histocompatibility Complex (MHC) and the functional regulatory landscape of the Fibroblast Growth …
Laboratory Techniques In Public Health: Bi-520 Introduction To Public Health Lab Manual, Anuradha Srivastava
Laboratory Techniques In Public Health: Bi-520 Introduction To Public Health Lab Manual, Anuradha Srivastava
Open Educational Resources
This laboratory manual for a foundations course Public Health is unique in the sense that very rarely, a foundations course in the field has a lab component offered with the lecture. This lab manual provides basic laboratory exercises that could be useful to introduce undergraduate students to the basics of public health laboratory practices.
Prosody And Attachment In Possessive Structures, Elizabeth Keeton, Katy Carlson
Prosody And Attachment In Possessive Structures, Elizabeth Keeton, Katy Carlson
2021 Celebration of Student Scholarship - Oral Presentations
In this project, we are studying the effect that prosodic boundaries and accent location have on attachment in an ambiguous phrase like “the daughter of the pharaoh’s advisor.” Under high possessive attachment, the phrase could mean, “There’s a daughter of the pharaoh, and we’re talking about her advisor.” If there is low possessive attachment instead, the phrase could be understood as, “There’s a pharaoh’s advisor, and we’re talking about his/her daughter.” In an auditory questionnaire, participants will listen to 24 dialogues, with the phrases preceded by the question “Who was it?” We placed contrastive accents on the first noun (“the …
Factors For Success In Rural Tourism: A Case Study Of Eastern Kentucky, Bethany Allen, Vijay Subramaniam
Factors For Success In Rural Tourism: A Case Study Of Eastern Kentucky, Bethany Allen, Vijay Subramaniam
2021 Celebration of Student Scholarship - Oral Presentations
This research study examines the variables of tourism that influence a traveler’s decision when traveling in Eastern Kentucky, specifically Morehead, Kentucky. Morehead is a destination with great potential to be built into a prominent location for tourism in Kentucky. To best understand the potential of the area, the resources available and the existing tourism locations were accessed to build the foundation of this project. Successful tourism destinations around the state of Kentucky have been assessed to determine what factors contribute to their success as well as what tactics/resources the businesses use to draw people in. In comparison to successful tourism …
Factors Associated The Underrepresentation Of Female Head Coaches In Intercollegiate Athletics, Chloe Whitlock, Steve Chen
Factors Associated The Underrepresentation Of Female Head Coaches In Intercollegiate Athletics, Chloe Whitlock, Steve Chen
2021 Celebration of Student Scholarship - Oral Presentations
Past studies had shown the underrepresentation of females in the coaching profession. The purpose of this study was to examine the contributory factors to the underrepresentation of female head coaches in intercollegiate athletics. To further examine this issue, two studies were conducted to examine the perceptions of 124 current NCAA Division-I athletic coaches and 163 high school educators. Based on collegiate coaches’ responses, the factor analysis identified four important constructs that contribute to the success of female coaches’ job obtainment. According to the results of the second study, the high school educators (n = 163) believed there were gender biases …
Decade Long Monitoring Of Active Galactic Nuclei With Swift, Tithi Patel, Dirk Grupe
Decade Long Monitoring Of Active Galactic Nuclei With Swift, Tithi Patel, Dirk Grupe
2021 Celebration of Student Scholarship - Oral Presentations
I will report decade-long monitoring campaigns with the NASA Neil-Gehrels Swift mission of about 100 Active Galactic Nuclei (AGN). Swift has started with monitoring some AGN since 2005. This long-term monitoring project has enabled us to catch AGN in extreme high and low X-ray flux states allowing to trigger follow-up observations by XMM-Newton, NuSTAR, HST. While this program has led in the past to at least one trigger per year, no AGN was found with extreme variability. I will also give a brief overview of the causes of this extreme variability.
1st Place Contest Entry: Psychogenic Non-Epileptic Seizures Disorder: Treatment After The Diagnostic Odyssey, Heather Andrini, Ashley Okhovat, Sydni Au Hoy
1st Place Contest Entry: Psychogenic Non-Epileptic Seizures Disorder: Treatment After The Diagnostic Odyssey, Heather Andrini, Ashley Okhovat, Sydni Au Hoy
Kevin and Tam Ross Undergraduate Research Prize
This is Heather Andrini, Ashley Okhovat, and Sydni Au Hoy's submission for the 2021 Kevin and Tam Ross Undergraduate Research Prize, which won first place. It contains thier essay on using library resources, a summary of their research project on psychogenic non-epileptic seizures (PNES) disorder, and their works cited list.
Heather, Ashley, and Sydni are juniors at Chapman University, majoring in Biological Sciences. Their faculty mentor is Dr. Gregory Goldsmith.
Mrna Vaccinations For The Prevention Of Viral Infections, Isaac Underhill
Mrna Vaccinations For The Prevention Of Viral Infections, Isaac Underhill
Senior Honors Theses
mRNA vaccines for the prevention of infection disease have gained significant traction in the last three decades, specifically with the recent emergency approval of two COVID-19 vaccines (Oliver, Sara E et al., 2020; Rauch et al., 2018a). mRNA vaccines occupy a unique space in immunology because of their utilization of cellular mechanisms to produce viral proteins, and their simplicity and ease of manufacture (Cullis & Hope, 2017). These vaccines have shown strong humoral and cell-mediated adaptive immune responses (Rauch et al., 2018b) . In addition, side effects of the vaccines have been limited and subject response is manipulatable by varying …
Nvp-Bez235 Or Jaki Treatment Leads To Decreased Survival Of Examined Gbm And Bbc Cells, Neftali Vazquez, Alma Lopez, Victoria Cuello, Michael W. Persans, Erin Schuenzel, Wendy Innis-Whitehouse, Megan Keniry
Nvp-Bez235 Or Jaki Treatment Leads To Decreased Survival Of Examined Gbm And Bbc Cells, Neftali Vazquez, Alma Lopez, Victoria Cuello, Michael W. Persans, Erin Schuenzel, Wendy Innis-Whitehouse, Megan Keniry
Biology Faculty Publications and Presentations
Cancer cells almost universally harbor constitutively active Phosphatidylinositol-3 Kinase (PI3K) Pathway ac-tivity via mutation of key signaling components and/or epigenetic mechanisms. Scores of PI3K Pathway in-hibitors are currently under investigation as putative chemotherapeutics. However, feedback and stem cell mechanisms induced by PI3K Pathway inhibition can lead to reduced treatment efficacy. To address therapeutic barriers, we examined whether JAKi would reduce stem gene expression in a setting of PI3K Pathway inhibition in order to improve treatment efficacy. We targeted the PI3K Pathway with NVP-BEZ235 (dual PI3K and mTOR inhibitor) in combination with the Janus Kinase inhibitor JAKi in glioblastoma (GBM) and …