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Full-Text Articles in Medicine and Health Sciences
Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman
Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman
Honors Theses
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that affects over 5 million individuals in the United States alone. While AD is primarily thought of as a disease that destroys neural networks required for memory recall and formation, AD also cause impairment in emotional regulation, cognitive flexibility, and executive function pathways. The cause of AD is unknown; however, the allele ApoE4 has been identified as a risk factor for the onset of AD. ApoE4 provides a valuable opportunity to study AD through animal models. This thesis utilized a human ApoE4 transgenic rat model (hApoE4) to investigate the biological and behavioral …
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Honors Theses
Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …