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- Ablation (1)
- Bioimpedance (1)
- Conserved contacts network (1)
- Electroporation (1)
- Greek-key topology (1)
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- Impedance sensor (1)
- Irreversible electroporation (1)
- Melanoma‑associated antigen 4 (1)
- Molecular dynamics (1)
- Myeloid derived suppressor cells (1)
- New York esophageal squamous cell carcinoma‑1 (1)
- Non‑small cell lung cancer (1)
- Protein folding (1)
- Protein structural stability (1)
- Simulated annealing (1)
- Tumor therapy (1)
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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Myeloid-Derived Suppressor Cells Infiltration In Non-Small-Cell Lung Cancer Tumor And Mage-A4 And Ny-Eso-1 Expression, Zhenbo Hou, Xiao Liang, Xinmei Wang, Ziqiang Zhou, Guilan Shi
Myeloid-Derived Suppressor Cells Infiltration In Non-Small-Cell Lung Cancer Tumor And Mage-A4 And Ny-Eso-1 Expression, Zhenbo Hou, Xiao Liang, Xinmei Wang, Ziqiang Zhou, Guilan Shi
Bioelectrics Publications
Cancer/testis antigens melanoma‑associated antigen 4 (MAGE‑A4) and New York esophageal squamous cell carcinoma‑1 (NY‑ESO‑1) are of clinical interest as biomarkers and present valuable targets for immunotherapy; however, they are poor prognostic markers in non‑small cell lung cancer (NSCLC). In addition, myeloid derived suppressor cells (MDSCs) are recognized as a key element in tumor escape and progression. The aim of the present study was to investigate the diagnostic and prognostic value of MAGE‑A4 and NY‑ESO‑1, and their association with MDSCs in NSCLC samples. The expression levels of MAGE‑A4 and NY‑ESO‑1, and the infiltration of MDSCs (CD33+), were analyzed by immunohistochemistry of …
Network Approaches To Elucidate The Determinants Of Protein Topology And Stability, Zeinab Haratipour
Network Approaches To Elucidate The Determinants Of Protein Topology And Stability, Zeinab Haratipour
Chemistry & Biochemistry Theses & Dissertations
Predicting three-dimensional structures of proteins from sequence information alone, remains one of the most profoundly challenging and intensely studied problems in basic science. It has uniquely garnered the interdisciplinary efforts of biologists, biochemists, computer scientists, mathematicians and physicists. The advancement of computational methods to study fundamental features of proteins also enables insights that are either difficult to explore experimentally or complimentary to further interpret experimental data. In the present research and through the combined development and application of molecular dynamics and network science approaches we aimed to elucidate the role of geographically important amino acids and evolutionarily conserved long-range interactions …
Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin
Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin
Biomedical Engineering Theses & Dissertations
Nanosecond pulsed electric field (nsPEF) for cancer therapy is characterized by applications of high voltage pulses with low pulsed energy to induce non-thermal effects on tissues such as tumor ablation. It nonthermally treats tissues via electroporation. Electroporation is the increase in permeabilization of a cell membrane due to the application of high pulsed electric field. The objective of this study was to investigate the effect of nsPEF on tissue by monitoring the tissue’s impedance in real-time. Potato slices (both untreated and electroporated), and tumors extracted from female BALBc mice were studied. 100ns, 1-10kV pulses were applied to the tissues using …