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Full-Text Articles in Medicine and Health Sciences
Safety And Efficacy Of Silver-Coated Biomaterials In Vivo, Megan Klem, Darien L. Seidman, Rahyan Mahmoud, Manuella Adu, Lei Yu, Jeffrey Hettinger, Renee M Demarest
Safety And Efficacy Of Silver-Coated Biomaterials In Vivo, Megan Klem, Darien L. Seidman, Rahyan Mahmoud, Manuella Adu, Lei Yu, Jeffrey Hettinger, Renee M Demarest
Rowan-Virtua Research Day
Overtreatment and overuse of antibiotics in healthcare and agricultural settings have contributed to the selective pressure on bacterial strains to develop resistance. Resistance can develop as a result of mutations and subsequent resistance genes that allow bacteria to survive against antibiotics. Novel silver-oxide coatings were developed and were previously demonstrated to prevent adhesion of gram-negative bacteria (Escherichia Coli and Pseudomonas Aeruginosa) to the disc, but did not prevent gram-positive bacterial adherence (Streptococcus Aureus). In order to determine whether the silver-oxide coatings are bacterial static and may be preventing progression to biofilm formation, in vivo analysis of S. Aureus attached to …
The Regulation Of The Ospz And Orf-2 Promoters In The Shigella Flexneri By The Virulence Factor Virb, David Basta, Helen J. Wing
The Regulation Of The Ospz And Orf-2 Promoters In The Shigella Flexneri By The Virulence Factor Virb, David Basta, Helen J. Wing
Undergraduate Research Opportunities Program (UROP)
Shigella flexneri is a pathogenic bacterium that is the causative agent of shigellosis, an illness characterized by severe dysentery. Shigella carries many of its virulence genes on a large virulence plasmid and consequently this plasmid is the focus of research in the Wing lab. My research focuses on the transcriptional regulation of a newly identified gene called ospZ. This gene’s protein product is secreted outside the bacterial cell and assists in polymorphonuclear leukocyte migration, a function that is believed to enhance the virulence of Shigella. Many genes encoded by the Shigella virulence plasmid are regulated by the transcription factor VirB, …