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Obesity

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Full-Text Articles in Medicine and Health Sciences

Ventromedial Hypothalamic Npy Y2 Receptor In The Maintenance Of Body Weight In Diet-Induced Obesity In Mice, Yulin Li, Xu-Feng Huang, Chao Deng, Qing Wang, Timothy South, Yinghua Yu Sep 2012

Ventromedial Hypothalamic Npy Y2 Receptor In The Maintenance Of Body Weight In Diet-Induced Obesity In Mice, Yulin Li, Xu-Feng Huang, Chao Deng, Qing Wang, Timothy South, Yinghua Yu

Xu-Feng Huang

This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice were fed a high-fat diet for 8 weeks and then classified as diet-induced obese (DIO) or diet-resistant (DR) mice according to the highest and lowest body weight gainers, respectively. The DIO and DR mice were then randomly divided into three groups each and either continued on their high-fat diet ad libitum (DIO-H …


Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South Sep 2012

Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South

Xu-Feng Huang

The cannabinoid CB1 receptor has been implicated in the regulation of appetite and the consumption of palatable foods. This experiment aimed to explore the involvement of the CB1 receptor in the early and late stages of high fat diet-induced obesity in C57BL/6 mice. The C57Bl/6 mice were placed on a high fat (HF) or low fat/high carbohydrate (LF) diet for 3 or 20 weeks. Quantitative autoradiography revealed that binding of [3H] CP-55,940 (CB1 receptor ligand) was elevated following 3 weeks of HF feeding in areas including the medial/ventral anterior olfactory nucleus (22.1%), agranular insular cortex (24.0%) and the hypothalamus (31.5%) …


G Protein-Coupled Receptor 12 Deficiency Results In Decreased Energy Expenditure, Dyslipidemia And Obesity In Mice, L. Svensson, Xu-Feng Huang, M Jonnson, M Bjursell, M Boholooly, J Tornell, V Surve, A Gerdin Sep 2012

G Protein-Coupled Receptor 12 Deficiency Results In Decreased Energy Expenditure, Dyslipidemia And Obesity In Mice, L. Svensson, Xu-Feng Huang, M Jonnson, M Bjursell, M Boholooly, J Tornell, V Surve, A Gerdin

Xu-Feng Huang

No abstract provided.


Differential Expression Of Dopamine D2 And D4 Receptor And Tyrosine Hydroxylase Mrna In Mice Prone, Or Resistant, To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, Yinghua Yu, Katerina Zavitsanou, Mei Han, Leonard Storlien Sep 2012

Differential Expression Of Dopamine D2 And D4 Receptor And Tyrosine Hydroxylase Mrna In Mice Prone, Or Resistant, To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, Yinghua Yu, Katerina Zavitsanou, Mei Han, Leonard Storlien

Xu-Feng Huang

The present study examined brain dopamine D2 and D4 receptor and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice. Twenty-eight mice were fed a high-fat diet (HF: 40% of calories from fat) for 6 weeks and then classified as cDIO (n = 8) or cDR (n = 8) mice according to the highest and lowest body weight gainers, respectively. Seven mice were fed a low-fat diet (LF: 10% of calories from fat) and used as controls. After 20 weeks of feeding, visceral fat per gram of initial body weight was significantly higher in …


Diets High In Oat-Derived Beta-Glucan Promote Negative Energy Regulatory Pathway Of Hypothalamic Npy System In Chronic Diet-Induced Obesity In Mice, Xu-Feng Huang, Timothy South, Eleanor Beck, Marijka Batterham, K. Grinter, Linda Tapsell Sep 2012

Diets High In Oat-Derived Beta-Glucan Promote Negative Energy Regulatory Pathway Of Hypothalamic Npy System In Chronic Diet-Induced Obesity In Mice, Xu-Feng Huang, Timothy South, Eleanor Beck, Marijka Batterham, K. Grinter, Linda Tapsell

Xu-Feng Huang

No abstract provided.


Dopamine Transporter And D2 Receptor Densities In Mice Prone Or Resistant To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, F Chen, A Lawrence, Katerina Zavitsanou, Chao Deng, Hong-Qin Wang, Yinghua Yu Sep 2012

Dopamine Transporter And D2 Receptor Densities In Mice Prone Or Resistant To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, F Chen, A Lawrence, Katerina Zavitsanou, Chao Deng, Hong-Qin Wang, Yinghua Yu

Xu-Feng Huang

No abstract provided.