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University of Nebraska - Lincoln
Department of Animal Science: Dissertations, Theses, and Student Research
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Genome-Wide Analysis Of The Variation In Host Genetics In Response To Experimental Challenges With Porcine Circovirus 2b, Taylor B. Engle
Genome-Wide Analysis Of The Variation In Host Genetics In Response To Experimental Challenges With Porcine Circovirus 2b, Taylor B. Engle
Department of Animal Science: Dissertations, Theses, and Student Research
Porcine circovirus is the primary causative agent responsible for inducing a group of associated diseases known as porcine circovirus associated diseases (PCVAD), which can have detrimental effects on production efficiency as well as lead to mortality. The variation in host genetics plays a role in the ability to initiate an effective immune response. The objective of this research was to identify major genetic variants and genes that influence immune response and PCVAD susceptibility. Commercial crossbred pigs (n=974) were experimentally infected with a PCV2b strain to analyze genetic sources of variation in PCVAD susceptibility. The strain used for experimental infection was …