Medicine and Health Sciences Commons^™

Transcriptomic Profiling Of Fibropapillomatosis In Green Sea Turtles (Chelonia Mydas) From South Texas, Nicholas B. Blackburn, Ana C. Leandro, Nina Nahvi, Mariana A. Devlin, Marcelo Leandro, Ignacio Martinez Escobedo, Juan M. Peralta, Jeff George, Thomas W. Demaar, John Blangero, Megan Keniry, Joanne E. Curran

School of Medicine Publications and Presentations

Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in …

Molecular Characterization Of A Marine Turtle Tumor Epizootic, Profiling External, Internal And Postsurgical Regrowth Tumors, Kelsey Yetsko, Jessica A. Farrell, Nicholas B. Blackburn, Liam Whitmore, Maximilian R. Stammnitz, Jenny Whilde, Catherine B. Eastman, Devon Rollinson Ramia, Ana C. Leandro

School of Medicine Publications and Presentations

Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression.

Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially …

Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das

Doctoral Dissertations

Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for …

Evaluation Of The Attitudes Of Veterinary Students Towards Cancer In Animals Using A Cancer Attitude Scale For Animals, İbrahi̇m Kiliç, İbrahi̇m Demi̇rkan, Aysun Çevi̇k Demi̇rkan, Si̇nan Saraçli

Turkish Journal of Veterinary & Animal Sciences

The aim of this descriptive study was to examine the attitudes of veterinary undergraduate students towards cancer in animals with cognitive, affective, and behavioral dimensions by a new cancer attitude scale for animals approach. Questionnaires, as data collection tools, were applied to 205 students training to be veterinary surgeons at Afyon Kocatepe University, Faculty of Veterinary Medicine, who were selected by systematic random sampling method. Validity-reliability analysis and t-test as well as ANOVA were used in addition to descriptive statistics for the data analysis. The students? general attitudes to cancer were (X = 3.65) greater than the midscore, 3, according …

An Examination Of Chimpanzee Use In Human Cancer Research, Jarrod Bailey

Jarrod Bailey, PhD

Advocates of chimpanzee research claim the genetic similarity of humans and chimpanzees make them an indispensable research tool to combat human diseases. Given that cancer is a leading cause of human death worldwide, one might expect that if chimpanzees were needed for, or were productive in, cancer research, then they would have been widely used. This comprehensive literature analysis reveals that chimpanzees have scarcely been used in any form of cancer research, and that chimpanzee tumours are extremely rare and biologically different from human cancers. Often, chimpanzee citations described peripheral use of chimpanzee cells and genetic material in predominantly human …

Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens

Martha McMillan Research Papers

No abstract provided.

Treatment Of Canine Transmissible Venereal Tumor Using L-Asparaginase, Prednisone, And Surgery In A Clinical Chemotherapy-Resistant Case, Daniella Matos Da Silva, Mhayara Samile De Oliveira Reusing, Aline Iara Franciosi, Carlos Edvardo Penner Belo, Kamilá Alcala Gonçalves, Renato Silva De Sousa, Simone Domit Guérios

Turkish Journal of Veterinary & Animal Sciences

A 4-year-old intact female dog was presented with a vaginal transmissible venereal tumor (TVT) that had clinically developed multidrug resistance to vincristine, vinblastine, and doxorubicin. Complete remission was obtained with combined-modality therapy with surgery, L-asparaginase, and prednisone.