Medicine and Health Sciences Commons^™

Gender Differences In Presenting Symptoms, Treatment, And Outcome In Myocardial Infarction, Alona Dalusung-Angosta

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purposes of this study were to compare the presenting symptoms, treatment, and outcome between men and women with MI. The study sample consisted of 300 patients (N = 300) who were diagnosed with MI in a county hospital in the Southwest area of the United States.

Chest pain, shortness of breath, sweating, and left arm pain were the most common symptoms reported by both genders. Men had more chest pain than their women counterparts (p = .022). No significant difference was found in the cardiac enzyme levels between both genders. Men had more Q wave changes during MI than …

Role Of Lipolysis And Lipogenesis In The Development Of Diet-Induced Obesity, Michael John Davies

Theses and Dissertations in Biomedical Sciences

Obesity is an increasingly common public health problem with approximately one-half of the American adult population overweight and one-quarter considered obese. This alarming trend has led researchers to determine potential causative factors of excess weight gain in humans. However, it is difficult to discern whether perturbations that result in obesity are the cause or simply the result of the obese state. Diet-induced obesity is one of the animal models that allow researchers to address temporal issues. Our laboratory utilizes a diet-induced obesity model in which Sprague-Dawley rats are placed on a purified moderately high fat diet and ultimately diverge into …

An Ultrastructural Survey Of The Nuchal Glands Of Rhabdophis Tigrinus (Serpentes: Colubridae), Kathleen A. Roberts

Biological Sciences Theses & Dissertations

Rhabdophis tigrinus, an Asian natricine snake, possesses a series of integumentary glands located in the nuchal skin. Previous studies indicated that the nuchal glands are of mesodermal origin, contain cardiac steroids analogous to bufotoxins found in the parotoid glands of toads, which are included in the snake's diet. The nuchal glands are defensive in function. Preliminary histological studies revealed differences in quality of the gland tissue compared to previous studies, and difference in fixation techniques were suspected. Seven specimens of R. tigrinus were fixed by perfusion using a conservative fixation process standard for electron microscopy. The nuchal gland series …

In Vitro And In Vivo Studies On Bone Formation, Charmaine Richman

Loma Linda University Electronic Theses, Dissertations & Projects

The research focus of this dissertation deals with two major issues relevant to osteoporosis, the most common metabolic bone disease. These two aspects are: 1) mechanisms that are involved in the regulation of peak bone density, and 2) evaluation of the in vivo effects of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) as a potential means to treat osteoporosis.

The first study compared two strains of inbred mice, one with high bone density and one with low bone density, to determine when and to what extent bone density accumulation during postnatal and pubertal growth contributed to the observed differences in bone …

Excisional Wound Healing And The Role Of Homeobox Genes, David Allen Lanning

Theses and Dissertations

The biochemical and physiologic mechanisms responsible for excisional wound contraction have been extensively studied but are not completely understood. Furthermore, the genes that regulate these processes are unknown. As a result, there are limited treatment options available for patients with diseases or conditions characterized by abnormal tissue contraction. In an attempt to improve our understanding of these mechanisms and identify some of the putative regulatory genes, we studied excisional wound healing in the mid-gestational fetal rabbit. These wounds normally do not contract nor are they associated with inflammation, fibrosis, or scar formation. However, we have been able to induce contraction, …

Study Of P53 Gain Of Function Mutations In P53-Null Astrocytes, Sang H. Choi

Theses and Dissertations

A number of recent studies suggest that expression of mutant p53 with mutations in certain codons show a gain of function and some of the characteristics of an oncoprotein. In order to study gain of function mutation and eliminate the potential of a dominant negative interaction with endogenous wild type p53 protein, p53 knockout mouse astrocytes were used. A retrovirus system was used to introduce mutant p53 genes into these p53-null astrocytes. Immunohistochemical staining and western blot experiments showed the expression of mutant p53 protein in these cells after infection with the mutant p53 retroviruses. Cell growth experiment did not …