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Full-Text Articles in Medicine and Health Sciences
Examining The Tissue-Level And Gross Phenotypic Effects Of The Connexin43i130t/+ Mutation On The Developing Mouse Skull, Sommer G.E. Jarvis
Examining The Tissue-Level And Gross Phenotypic Effects Of The Connexin43i130t/+ Mutation On The Developing Mouse Skull, Sommer G.E. Jarvis
Electronic Thesis and Dissertation Repository
The purpose of this study was to investigate the effects of reduced Connexin43 function on the developing skull phenotype, osteoblast and chondrocyte proliferation and differentiation, and to determine if a correlation exists between cell processes and gross morphology. Using the Cx43I130T/+mouse model, skull shape was analyzed using geometric morphometrics and cell proliferation and differentiation were assessed using immunohistochemistry at late embryonic and early post-natal stages. The largest shape changes between Cx43I130T/+ and wildtype mice were observed in the cranial base and facial skeleton. Changes infacial morphology correspond to reduced osteoblast differentiation. However, no changes in chondrocyte proliferation …
Evaluating The Pathological And Behavioural Consequences Of Injecting Amyloid Beta Oligomers In The Rat, Ryan S. Wong
Evaluating The Pathological And Behavioural Consequences Of Injecting Amyloid Beta Oligomers In The Rat, Ryan S. Wong
Electronic Thesis and Dissertation Repository
Alzheimer’s disease (AD) is the most common form of dementia and is characterized by progressive neuronal loss and cognitive decline. Currently, no therapeutic treatments are available and our understanding of the disease progression is still unclear. Amyloid beta oligomers (AβO) are potent neurotoxic proteins and may be a potential initiator of the progression of AD. The purpose of this project was to identify the spatial and temporal consequences of injecting AβO into the rat brain by evaluating pathological and behavioural outcomes. We hypothesized that injecting AβO into the rat brain will result in microglial response as well as behavioural and …