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Full-Text Articles in Medicine and Health Sciences
Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang
Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang
Loma Linda University Electronic Theses, Dissertations & Projects
[Abstract Not Included]
The Effect Of Chronic Hypoxia On Cardiac Function In The Fetal Ovine Heart, Rodney David Rodrigo
The Effect Of Chronic Hypoxia On Cardiac Function In The Fetal Ovine Heart, Rodney David Rodrigo
Loma Linda University Electronic Theses, Dissertations & Projects
It has been shown that long-term high altitude hypoxia during pregnancy was associated with a decrease in cardiac contractility in fetal sheep. Given that hypoxia caused apoptotic cell death in fetal and neonatal rat cardiomyocytes, the present study tested the hypothesis that chronic hypoxia during pregnancy increases apoptosis in the fetal sheep heart. Pregnant (d 30) sheep were divided between normoxic control and chronically hypoxic (maintained at high altitude, 3,820 m, PaO2: 60 Torr for 110 days) groups. Hearts were isolated from near-term (d 140) fetal sheep, and samples from all four chambers, right and left atria, and …
Age Related Changes In Contractile Sensitivity To Cyclic Gmp And Intracellular Calcium Compartmentalization In Ovine Arteries, Surya Margono Nauli
Age Related Changes In Contractile Sensitivity To Cyclic Gmp And Intracellular Calcium Compartmentalization In Ovine Arteries, Surya Margono Nauli
Loma Linda University Electronic Theses, Dissertations & Projects
The study examines the hypothesis that maturation changes the ability of cGMP to produce cerebral vasodilatation and alters the relative intracellular calcium pool sizes in ovine arteries. In ovine basilars taken from near-term fetal and young adult sheep, 8- pCPT-cGMP relaxed potassium- and serotonin-induced tone with pD2 values of 4.4±0.1 and 4.9±0.1 (fetal basilar) and 4.0±0.1 and 4.7±0.1 (adult basilar), respectively. In fura-2 loaded arteries, 8-pCPT-cGMP significantly lowered increases in cytosolic calcium concentration induced by serotonin but not potassium regardless of age. When calcium sensitivity was calculated in the same arteries as the slope of the relation between calcium concentration …
A Continued Investigation Of Craniofacial Growth In Infant Heart Transplant Recipients Receiving Cyclosporine, John Michael Cornali
A Continued Investigation Of Craniofacial Growth In Infant Heart Transplant Recipients Receiving Cyclosporine, John Michael Cornali
Loma Linda University Electronic Theses, Dissertations & Projects
Cyclosporine is an effective immunosuppressive drug that has found widespread application in organ transplantation. A couple of studies, however, have implicated cyclosporine as adversely affecting craniofacial growth in the pediatric population. The purpose of this follow-up study was to continue to evaluate the possible untoward effects of long-term use of cyclosporine on craniofacial growth in a group of infant heart transplantation recipients by re-evaluating as many subjects as possible from the original study and evaluating new subjects. A prospective group (N=29) of eighteen Caucasian subjects (7 female and 11 male, ages 6-15 years) and eleven Hispanic subjects (3 female and …
Assessment Of Immune System Involvement In Tourette Syndrome, Ashley Dawn Levine
Assessment Of Immune System Involvement In Tourette Syndrome, Ashley Dawn Levine
Loma Linda University Electronic Theses, Dissertations & Projects
Tourette syndrome (TS) is currently hypothesized to be the result of genetic and immunological components. This study investigated whether TS subjects produce IgG and IgA antibodies that bind to caudate nucleus, hippocampus, frontal cortex, cerebellum, thalamus, globus pallidus interior, exterior and putamen. Thirty- two children (14 TS, 7 family control, and 11 non-family control) and thirty-nine adults (11 TS, 14 family control, and 14 non-family control) were studied. Immunofluorescent studies were performed on basal ganglia tissue using serum from TS children and their family members. Brain antigens were prepared as two fractions (supernatant and pellet) and used as targets for …