Medicine and Health Sciences Commons^™

The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright

Loma Linda University Electronic Theses, Dissertations & Projects

Within the retina, the POU domain of transcription factors brn-3.0, brn-3.1, and brn-3.2 are present only in retinal ganglion cells. These genes are believed to be involved in establishing neural cell lineages in mammals. In this study brn-3.2 was examined by comparing the number of ganglion cells present during postnatal development in normal mice (+/+), in mice homozygous (-/-) for the brn-3.2 gene, and in adult mice with a heterozygous gene deletion (+/-) for brn-3.2. Optic nerve cross sections were imaged by electron microscopy, and axon profiles counted systematically by hand. These counts were then related to the nerve cross …

Regulation Of Connexin43 By Phosphorylation, Maithili M. Shah

Loma Linda University Electronic Theses, Dissertations & Projects

Gap junctions play a crucial role in embryogenesis, especially of the heart where connexin43 is thought to be important for its formation as well as synchronized contraction. Several reports have shown that connexin43 protein is phosphorylated on serine residues in vitro and in vivo.

Studies performed in our laboratory have demonstrated that cell-to-cell communication in cells expressing connexin43 can be controlled rapidly and reversibly by microinjection of active protein kinases or phosphatases that target serine or threonine residues. Phosphorylation by cAMP-dependent protein kinase (PKA) seems to favor channel opening, whereas the effect of protein kinase C (PKC) on channel gating …

Diagnosis And Treatment Of Swallowing Dysfunctions : Semg Cognitive Training As An Adjunct To Conventional Therapy, Vicky T. Nguyen

Loma Linda University Electronic Theses, Dissertations & Projects

This study compared surface electromyography (sEMG) cognitive training to conventional myofunctional therapy in controlling a swallowing dysfunction, commonly referred to as "tongue thrust". Nasal airway resistance (NAR) was assessed on every subject, to rule out mechanical obstruction that would prevent proper function. The scope of this investigation composed of evaluating baseline activity and dry swallowing patterns. Subjects were distributed to one of three treatment groups: sEMG cognitive training, conventional myofunctional therapy, and control, based on the degree of NAR (normal, mild, or moderate). Initial sEMG recordings were then taken on subjects that clinically demonstrated a tongue thrust habit to confirm …