Medicine and Health Sciences Commons^™

Evaluation Of Nitric Oxide In Respiratory Distress Syndrome, Kimberly S. Myruski

Loma Linda University Electronic Theses, Dissertations & Projects

Little is known of the effects of low concentrations of inhaled nitric oxide (NO) on pulmonary mechanics and lung volumes in premature newborn infants with lung disease. Cardiopulmonary function tests including blood gas analyses were obtained from eleven premature lamb models with respiratory distress syndrome to determine if compliance, airways resistance, tidal volume, functional residual capacity, and gas exchange were affected. The effect of inhaled NO on the direction of shunting through the ductus arteriosus was determined using echocardiography.

Twin lambs were cannulated with arterial and venous catheters and intubated with an endotracheal tube before delivery on gestational day 126-130 …

Regulation Of The Insulin-Like Growth Factor System By Retinoic Acid In Human Osteoblast Cells, Yuehua Zhou

Loma Linda University Electronic Theses, Dissertations & Projects

Retinoic acid (RA) is an important regulator of growth and differentiation in many cell types, including bone. However, its effects on human osteoblast cell growth and differentiation have not been well studied. Therefore, I investigated the effect of RA on proliferation and differentiation of normal human bone cells (HBCs) and human osteosarcoma, SaOS-2 cells. RA decreased baseline as well as serum-stimulated proliferation in normal HBCs. To determine the effect of RA on differentiation, expression of several osteoblastic differentiation markers were studied. RA decreased type I procollagen mRNA levels and l,25(OH)₂D₃-stimulated osteocalcin and alkaline phosphatase (ALP) mRNA …