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Full-Text Articles in Medicine and Health Sciences
Locus‐Specific Concordance Of Genomic Alterations Between Tissue And Plasma Circulating Tumor Dna In Metastatic Melanoma, Leslie Calapre, Tindaro Giardina, Cleo Robinson, Anna L. Reid, Zeyad Al-Ogaili, Michelle R. Pereira, Ashleigh C. Mcevoy, Lydia Warburton, Nicholas K. Hayward, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Benhur Amanuel, Melanie R. Ziman, Elin S. Gray
Locus‐Specific Concordance Of Genomic Alterations Between Tissue And Plasma Circulating Tumor Dna In Metastatic Melanoma, Leslie Calapre, Tindaro Giardina, Cleo Robinson, Anna L. Reid, Zeyad Al-Ogaili, Michelle R. Pereira, Ashleigh C. Mcevoy, Lydia Warburton, Nicholas K. Hayward, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Benhur Amanuel, Melanie R. Ziman, Elin S. Gray
Research outputs 2014 to 2021
Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for disease monitoring in melanoma. In this study, we compared the mutation profiles of tumor biopsies and plasma ctDNA from metastatic melanoma patients using custom sequencing panels targeting 30 melanoma-associated genes. Somatic mutations were identified in 20 of 24 melanoma biopsies, and 16 of 20 (70%) matched-patient plasmas had detectable ctDNA. In a subgroup of seven patients for whom matching tumor tissue and plasma were sequenced, 80% of the mutations found in tumor tissue were also detected in …
Fasting Salivary Glucose Levels Is Not A Better Measure For Identifying Diabetes Mellitus Than Serum Or Capillary Blood Glucose Levels: Comparison In A Ghanaian Population, Richard K.D. Ephraim, Enoch Odame Anto, Emmanuel Acheampong, Linda Ahenkorah Fondjo, Richmond B. Barnie, Samuel Asamoah Sakyi, Ambrose Asare
Fasting Salivary Glucose Levels Is Not A Better Measure For Identifying Diabetes Mellitus Than Serum Or Capillary Blood Glucose Levels: Comparison In A Ghanaian Population, Richard K.D. Ephraim, Enoch Odame Anto, Emmanuel Acheampong, Linda Ahenkorah Fondjo, Richmond B. Barnie, Samuel Asamoah Sakyi, Ambrose Asare
Research outputs 2014 to 2021
Aims/introduction: We compared the diagnostic performance and correlation between salivary, serum and capillary blood glucose of diabetes and non-diabetes patients. Early detection of diabetes mellitus (DM) contributes to the prevention of complications and management. Materials and methods: This case-control study was conducted among a total of 138 participants comprising 79 newly diagnosed diabetes patients (cases) and 59 non-diabetes patients (controls). Fasting salivary glucose (FSLG), fasting serum glucose (FSEG) levels and fasting capillary whole blood glucose (FCWBG) level were assayed for each participant. Results: The mean FSLG, FSEG and FCWBG levels were significantly higher among the cases compared to controls (p …