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Rapid Recovery Of Cerebral Blood Content And Oxygenation In Adults From Time-Resolved Near-Infrared Spectroscopy, David J. F. Cohen
Rapid Recovery Of Cerebral Blood Content And Oxygenation In Adults From Time-Resolved Near-Infrared Spectroscopy, David J. F. Cohen
Electronic Thesis and Dissertation Repository
Patient neurological outcomes following cardiac surgery are improved when near-infrared spectroscopy (NIRS) is used to optimize intraoperative cerebral oxygen delivery. However, current NIRS analysis methods have difficulties monitoring adult brains due to contamination from the extracerebral layer (ECL).
The objective of this thesis is to develop a time-resolved (TR) NIRS data analysis method for monitoring adult cerebral oxygen saturation (ScO2) and total hemoglobin (HbT) by assuming the head is composed of two layers – the ECL and the brain. We tested the validity of this assumption using in silico data from an adult human head using two approaches; a few-wavelength, …