Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Yerba mate (2)
- ALS (1)
- APACHE II (1)
- Amyotrophic lateral sclerosis (1)
- Antioxidants (1)
-
- Cancer treatment (1)
- Colorectal cancer (1)
- Epidermal Growth Factor Receptor Mutations (1)
- Extracorporeal photopheresis (1)
- General anesthetic (1)
- HPV (1)
- Human brain (1)
- Human papillomavirus (1)
- Inhibition (1)
- Ischemia-modified albumin (1)
- L-cartinine (1)
- Lung cancer (1)
- Mycobacterial enoyl reductase InhA (1)
- SOFA (1)
- Stem cells (1)
- Therapeutics (1)
- Tuberculosis (1)
- Vaccinations (1)
- Publication
- Publication Type
Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Correlation Of Ischemia-Modified Albumin With Sofa And Apache Ii Scores In Preoperative Patients With Colorectal Cancer, Masaaki Katoh, Kazuhiko Kotani, Alejandro Gugliucci, Hisanaga Horie, Russell Caccavello, Mamoru Takeuchi
Correlation Of Ischemia-Modified Albumin With Sofa And Apache Ii Scores In Preoperative Patients With Colorectal Cancer, Masaaki Katoh, Kazuhiko Kotani, Alejandro Gugliucci, Hisanaga Horie, Russell Caccavello, Mamoru Takeuchi
Faculty Publications & Research of the TUC College of Osteopathic Medicine
Purpose. Critical illnesses are assessed according to the sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II. Circulating ischemia-modified albumin (IMA) is a biomarker generated under ischemic and oxidative conditions and may reflect disease severity in preoperative patients. This study investigated the correlations of IMA with SOFA and APACHE II scores in inpatients admitted for colorectal surgery. Methods.We examined 27 patients with advanced colorectal cancers (mean age 69 years, men/women = 15/12). Correlations between SOFA and APACHE II scores in addition to preoperative serum IMA and C-reactive protein (CRP) levels were analyzed. Results …
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Science Journal of the Lander College of Arts and Sciences
The HPV virus is said to be the cause of many infections, warts, and cancers. In addition to the fact that the treatment for HPV is not always successful, not every individual knows that s/he is infected and is very likely to infect his or her partner, too. This is one factor that explains why 14 million people each year in America alone contract HPV and makes cervical cancer so threatening to many people worldwide. In light of this and the known dangers of cervical, anal, vaginal and penile cancers, the HPV vaccine was created to prevent an infection of …
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Science Journal of the Lander College of Arts and Sciences
Isoniazid (INH), one of two first-line drugs used to treat tuberculosis (TB), has been shown to be a potent inhibitor of InhA, the mycobacterial enoyl reductase. However, the increasing resistance to INH makes it imperative to find alternative drugs that are as effective as the first-line drugs, yet active against INH-resistant strains. Since InhA has been validated as an excellent target of TB, there have been attempts to find novel inhibitors of InhA. Through rational drug design, a variety of high affinity InhA inhibitors were synthesized. Triclosan itself was observed to be a suboptimal inhibitor of InhA with a K …
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
The Science Journal of the Lander College of Arts and Sciences
Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease which affects approximately 30,000 Americans at any given time (alsa.org, 2010). The etiology of this terminal disease unfortunately remains an unsolved mystery and has therefore severely limited the ability to find a cure. The use of stem cells to regenerate neurons has been vastly studied and have produced very promising results. However, its practicality as a cure or treatment for neurodegenerative diseases, such as ALS, is greatly compromised. Three different therapies involving stem cells were examined, Embryonic Stem Cells (ESC), induced pluripotent stem cells, (iPSC) and direct reprogramming of adult …
Apoptotic Neurodegeneration In The Developing Human Brain: Possible Role Of General Anesthetics In Its Genesis, And Of L-Carnitine In Its Reversal, Yisroel Yitzchok Rosenfeld
Apoptotic Neurodegeneration In The Developing Human Brain: Possible Role Of General Anesthetics In Its Genesis, And Of L-Carnitine In Its Reversal, Yisroel Yitzchok Rosenfeld
The Science Journal of the Lander College of Arts and Sciences
Recent studies suggest that general anesthetic (GA) agents administered to developing rats, through its mechanism as an NMDA antagonist or a GABAa mimetic, may damage developing neural cells by inducing a higher rate of programmed cell death (apoptosis). Similar heightened degeneration was also apparent in higher primates such as the monkey. This warrants strong concern, as every year thousands of pregnant women and children below 1 year of age undergo a surgical procedure in which GAs are used. A spike in neuroapoptosis may lead to long term cognitive deficiencies lingering into adulthood. Are humans vulnerable to these affects? Different pathways …
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
The Science Journal of the Lander College of Arts and Sciences
Lung Cancer is the most common global cause of cancer related deaths in men and women (Markus, Alain, 2013). As standard radiation and chemotherapy have proved ineffective, novel target therapies are in the midst of development. This review will analyze the success of the inhibitor drugs targeting the Epidermal Growth Factor Receptor (EGFR) mutation, commonly found amongst Lung Cancer patients. Numerous studies and reviews are utilized to determine the cause of the 10% success rate currently exhibited for these drugs. The L858R and E746-A750 point mutations and deletions respectively, were found prevalent in responsive patients as well as clinical-pathological features …
Current Research Of Extracorporeal Photopheresis And Future Applications, Chaim Lederer
Current Research Of Extracorporeal Photopheresis And Future Applications, Chaim Lederer
The Science Journal of the Lander College of Arts and Sciences
Photopheresis, also known as Extracorporeal Photopheresis (ECP) is making inroads in treatment of previously untreatable diseases. As the medical world has delved deeper into, Although the mechanisms of photopheresis are largely unknown, increasingly detailed studies have proven its efficacy. The lack of side effects has made photopheresis an ideal option for patients. The treatment is also versatile enough that it can be used as a mono-therapy or as a supplement to other traditional therapies. The use of photopheresis has been proven successful in the treatment of cutaneous T-cell lymphoma (CTCL) and graft-versus-host disease (GvHD), and is currently being administered for …
Aqueous Maté Extract Decreases The Viability Human Breast Cancer Through Apoptosis And Cancer Repression, Kenisha Nisbett, Amina Sadik
Aqueous Maté Extract Decreases The Viability Human Breast Cancer Through Apoptosis And Cancer Repression, Kenisha Nisbett, Amina Sadik
College of Osteopathic Medicine (TUN) Publications and Research
Ilex paraguariensis, also known as Yerba Maté, is a subtropical plant native to South America. In various South American cultures, the leaves of Yerba Maté tree are roasted to make a traditional herbal tea. Several studies have been conducted to elucidate the beneficial effects of this beverage. A recent study has shown that saponins isolated from Yerba Maté extract induce apoptosis in human colon cancer cells, while another study indicated that the consumption of Maté tea causes higher incidence of esophageal cancer. Our study looked into the effects Yerba Maté extract had on human breast cancer cells. The findings …
The Effect Of Maté On Enzymes Involved In The Recovery From Oxidative Stress, Amina Sadik, Theodore Chang
The Effect Of Maté On Enzymes Involved In The Recovery From Oxidative Stress, Amina Sadik, Theodore Chang
College of Osteopathic Medicine (TUN) Publications and Research
In comparing the effect of Maté to that of green tea, it has been shown that Maté has higher anti-oxidative properties. We have shown that the extract of Yerba Maté, paraguariensis, leaves does indeed have strong anti-oxidative properties through the evaluation of its scavenging activity and its ability of assist cardiomyocytes in their recovery from induced oxidative stress using both spectroscopy, a colorimetric assay and flow cytometry. In order to elucidate the mechanism behind this action, we quantified the enzymes known to be expressed naturally by cells under oxidative stress such as glutathione peroxidase, superoxide dismutase, and catalase. These enzymes …