Medicine and Health Sciences Commons^™

Single-Case Pilot Study For Longitudinal Analysis Of Referential Failures And Sentiment In Schizophrenic Speech From Client-Centered Psychotherapy Recordings, Travis A. Musich

Dissertations

Though computational linguistic analyses have revealed the presence of distinctly characteristic language features in schizophrenic disordered speech, the relative stability of these language features in longitudinal samples is still unknown. This longitudinal pilot study analyzed schizophrenic disordered speech data from the archival therapy audio recordings of one patient spanning 23 years. End-to-end Neural Coreference Resolution software was used to analyze transcribed speech data from three therapy sessions to identify ambiguous pronouns, referred to as referential failures, which were reviewed and confirmed by multiple raters. Speech samples were analyzed using Google Cloud Natural Language API software for sentiment variables (i.e., score, …

Transplantability In Burdened Populations: A Regional Analysis Of The Robotic-Assisted Kidney Transplant Impact On Access Given Socioeconomic And Demographic Factors, Earnest James Davis Jr.

Dissertations

Introduction/Background

The social contract of health (SCOH) in America that governs healthcare interactions has listed toward provider organizations and away from the patient. End stage renal disease treatment provides an explicatory case to examine an unbalanced SCOH. The study evaluates whether the robot-assisted kidney transplantation (RAKT) technique allows for patients with higher body mass indices and of burdened socioeconomic and sociodemographic status improved access to transplant compared to traditional open kidney transplant (OKT).

Methods

The study set combined extant data for patients transplanted at Chicago from two data sets. Investigators used independent t-tests, chi-squared tests, survival analysis, analysis of frequencies, …

Liquid Biopsies For Type 2 Diabetes Mellitus: Biomarkers For Disease Risk And Diagnosis, Stephanie Chidester

Dissertations

Background: Type 2 diabetes mellitus (T2DM) has reached epidemic proportions in the United States. There is a critical need for earlier and more effective screening and diagnostic tools. Innovative liquid biopsy technologies may play a key role in meeting this need. Liquid biopsies are a non-invasive, adjunctive tool for determining diagnosis, prognosis, and therapeutic response. This dissertation focuses on two potential applications of liquid biopsy technologies to T2DM: (1) epigenome-wide association studies to identify epigenetic markers of risk for T2DM, and (2) extracellular vesicle (EV)-based biomarker studies to identify and detect markers associated with T2DM development and progression. Dissertation studies: …

Characterization, Implementation, And Impact Of Low Stimulation Precautions In Acute Neurological Injury, Alexis Kurek

Dissertations

Recommendations provided by clinical and professional organizations that encourage providing patients with a low stimulation environment following acquired brain injury are prevalent but supported by expert opinion only. Such recommendations are based on extrapolation of what is known about physiological response to environmental stimuli, however such findings are not specific to the patients with acquired brain injury. Recommendations for low stimulation environments lack guidance for their application and implementation of precautions, and there have been no studies investigating their effectiveness at improving clinical outcomes.

The objective of this study is to determine what patient characteristics are associated with prescription of …

Cardiac Electrophysiology: Exploring Racial And Gender Outcomes Of Treatment Of Paroxysmal And Persistent Atrial Fibrillation Using Sotalol And Dofetilide, Nicole Lanette Bradford-Love

Dissertations

Purpose

The purpose of this study is to explore the association between gender and racial lines in the conversion and sustainment of normal sinus rhythm (NSR) from paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation using the anti-arrhythmic drugs (AADs) sotalol and dofetilide.

Methods

A secondary data analysis was performed to assess the relationships of the independent and dependent variables listed above. Using SPSS v. 24 descriptive statistics were obtained and initially evaluated for accuracy with histograms. A cross-tabulation frequency table was produced to determine the number of variables that fell into each dependent category. Following this, the frequencies were …

Pinch Span And Force: Normative Data, Requirements For Functional Tasks And Life Roles, And The Influence Of Carpometacarpal Joint Osteoarthritis, Nancy Hock

Dissertations

The three studies that form this dissertation build knowledge related to functional pinch. Study 1 provides normative data for the Baseline® 5-Position Hydraulic Pinch Meter, which may be used in clinical practice. The data collected in this study demonstrate the relationship between lateral pinch strength and age and reveal that strength decreases with age in both males and females. Through examination of the lateral pinch force produced at the 5 different pinch spans, it was found that the strongest lateral pinch strength was produced at 4-5 cm of pinch span. This information can be used by clinicians as they modify …

Early Identification And Intervention In Patients With Atrial Fibrillation Using An Implantable Cardiac Monitor To Significantly Improve Guideline-Based Anticoagulation Therapy In An Outpatient Cardiology Clinic, Lisa Alvarez

Dissertations

The purpose of this research was to (a) examine the demographics of patients receiving care in an outpatient cardiology clinic, (b) describe the relationship between the atrial fibrillation (AF) and other variables (e.g., BMI), (c) examine the frequency and the length of time to AF diagnosis in patients implanted with an implantable cardiac monitoring (ICM) device, (d) observe provider patterns of treatment with oral anticoagulants (OACs), and (e) investigate documented considerations to either diagnose or rule out OSA in a group of outpatient AF patients in a cardiology clinic.

Background: AF is largely undiagnosed but can cause major morbidity and …

Hybrid Model - Statistical Features And Deep Neural Network For Brain Tumor Classification In Mri Images, Mustafa Rashid Ismael

Dissertations

A brain tumor is the most common disease that affects the central nervous system (CNS), the brain, and spinal cord. It can be diagnosed using the safest and most reliable imaging modality, the Magnetic Resonance Imaging (MRI), by radiologists who may use the assistance of computer-aided diagnosis (CAD) tools. Automated diagnosis is sought because it is essential to overcome the drawbacks of the manual diagnosis, such as time and the stress of viewing MRI images for long hours, and the human error potential. Image analysis and machine learning algorithms are tools that can be used to build an intelligent CAD …

Peri-Operative Regional Nerve Blocks (Pnb) In The Treatment Of Pain In Patients Undergoing Operative Fixation Of Lower Extremity Fractures, Joshua K. Radi

Dissertations

This research explores current approaches to managing pain control in patients undergoing operative fixation of lower extremity fractures. As opioid use in the U.S. and abroad increases, alternative methods of treating and preventing opioid requirements are being examined. Patients with lower extremity fractures are susceptible to nonunion when anti-inflammatories are consumed, so alternative approaches are warranted. One such alternative, a peri-operative regional nerve block (PNB), is accomplished by injecting local anesthetic adjacent to one or more peripheral nerves supplying the area of the fracture to decrease pain (Fowler, Symons, Sabato, & Myles, 2008). The goal of this research was to …

Compressive Sensing Framework For Mass Spectrometry Data Analysis, Khalfalla Ahmad Kh. Awedat

Dissertations

Mass Spectrometry (MS) data is ideal for identifying unique bio-signatures of diseases. However, the high dimensionality of MS data hinders any promising MS-based proteomics development. The goal of this dissertation is to develop an accurate classification tool by employing compressive sensing (CS). Not only can CS significantly reduce MS data dimensionality, but it also will allow for full reconstruction of original data. The framework developed in this work is based on using L2 and a mixed L2-L1 norms, allowing an overdetermined system to be resolved. The results show that the L2- based algorithm with regularization terms has a better performance …

Experimental Investigation On The Relationship Between Lead Exposure And Thyroids In Diabetes, Salah Sumar Ali Al-Zadjali

Dissertations

Lead exposure can cause multiple systemic toxicities, particularly affecting the hematopoietic, nervous and renal systems. However, its effects on the thyroid functions are not well elucidated and the published studies are controversial. In addition, although there are several experimental thyroid models, each one of them has its own limitations. Accordingly, in this dissertation, we investigated the possible relationship between lead exposure, thyroid functions and short-term systemic toxicity in two animal models, namely normal (non-diabetic) and diabetic animals. We also investigated the possibility of developing a hormonal thyroid model. In the non-diabetic model, Wistar rats were divided into five groups and …

Comparisons Of Three Analytical Techniques For Measuring Absolute And Relative Temperature Changes During Ultrasound Treatment, Michael G. Miller

Dissertations

Ultrasound is a thermal modality that utilizes acoustic energy to promote heating. While there are many factors that affect heating of body tissues, the effects of skinfold thickness and skin temperature upon ultrasound heating have not been studied extensively. In addition, while temperature typically follows a linear trend, past research typically uses ANOVA or regression analysis to examine this relationship; but these models examine the within-subject effects (time) and between effects (usually groups) at the group level, not the individual level. Therefore, the purposes of this study are to determine if skin temperature and skinfold thickness are predictors for intramuscular …

Use Of Monoclonal ∆-9-Tetrahydrocannabinol Antibodies Chemically Bound To A Polystyrene Surface Using Glutaraldehyde For The Purpose Of Extracting ∆-9-Tetrahydrocannabinol And ∆-9-Tetrahydrocannabinol Carboxylic Acid From Postmortem Whole Blood Samples For Analysis By Gas Chromatography Mass Spectrometry, Thomas Sidney Pittman

Dissertations

Quantitations of drugs and their respective metabolites in postmortem blood samples using gas chromatographic instrumentation is a primary analytical practice used to determine if drugs played a role in or were the cause of a victim's death. Postmortem blood samples often prove difficult to work with due to interfering substances formed during the putrefaction process. Attempts to eliminate interfering substances with present day extraction methods can be time-consuming, costly and often ineffective when dealing with drugs that exhibit toxicity or impairment at very low concentrations. This study was conducted using monoclonal antibodies chemically bound to a polystyrene surface to extract …

The Impact Of Systematically Varying The Duration Of Breath Samples During Infrared-Based Alcohol Breath Testing, Chris C. Clatterbuck

Dissertations

The present study set out to investigate the reliability and performance of the BAC DataMaster®, an infrared-based alcohol breath testing instrument. The focus of this study was to determine: (a) the impact of varying breath sample duration during testing, (b) if Blood Alcohol Concentration (BAC) levels produced by the DataMaster® (BAC_DM) are significantly different from BAC levels produced by analysis of whole blood (BAC_WB), and (c) if the relationship between BAC_DM estimates and BAC_WB is influenced by the amount of alcohol an examinee has ingested. Each of 27 participants was randomly assigned to one …

Diagnostic Issues With Attention Deficit Hyperactivity Disorder: Conditional Probabilities And A Measure Of Symptom Ratings, Margo Adams Larsen

Dissertations

Current assessment taxonomy, including the DSM -IV and the International Classification of Diseases (ICD) (World Health Organization, 1990) editions, have provided semistructured criteria sets to aid professionals in making a diagnosis of ADHD or ADD. The diagnostic taxonomy criteria, however, have resulted in a very heterogeneous population of Attention Deficit Hyperactivity Disordered (ADHD) individuals. Several studies have attempted to assess the behavioral syndromes— Attention Deficit Hyperactivity Disorder (ADHD)/Conduct Disorder (CD)/ Oppositional Defiant Disorder (ODD)—in terms of test or symptom sensitivity, specificity, positive predictive power, and negative predictive power (Landau, Milich, & Widiger, 1991; Milich, Widiger, & Landau, 1987; Waldman & …

The Validity Of The Adhd Section Of The Diagnostic Interview Schedule For Children, Ann M. Mcgrath

Dissertations

The purpose o f this study was to learn more about the validity o f the ADHD portion of the NIMH-DISCIV. In order to accomplish this goal, 58 youth participants were divided into three groups: (1) subjects who met criteria for ADHD based upon both the youth and the caretaker versions of the DISC; (2) subjects who met criteria for ADHD based upon the caretaker DISC, but not according to the youth DISC; and (3) subjects who did not meet criteria for ADHD according to either the youth or the caretaker DISC. Subjects in these groups were compared across parent …

The Clastogenic Effects Of Cyclophosphamide And A Sixty Hertz Electronagnetic Field On Bone Marrow Cells Of Cd-I Mice, Kevin K. Block

Dissertations

Extremely low frequency (ELF) electromagnetic fields (EMF) have been correlated with the induction of cancer in a number of epidemiological studies (Feychting and Ahlbom, 1993; T,m and Lee, 1994; London e t al. 1991; Lovely et al., 1994; Tomenius, 1986; Wertheimer and Leeper, 1979, 1982). Two hypothesis were tested in the present study. The first hypothesis tested was that exposure to a 7.3 G magnetic field for 24 hours would increase the frequency of clastogenic and/or mutagenic events in bone m arrow cells of mice. The second hypothesis tested was that exposure to a 7.3 G magnetic field for 24 …

The Bender Gestalt And Symbol Digit Modalities Tests As Cerebral Dysfunction Screening Instruments :A Comparative Evaluation, Bruce R. Wright

Dissertations

Problem

One of the problems confronting the psychologist in an institutional setting is the selection of appropriate instruments for the screening and diagnosis of a variety of psychological problems. Among the more subtle and yet far-reaching problems of this sort are those associated with disease, trauma, or congenital defect of the central nervous system. It was the purpose of this study to evaluate the usefulness of two well-known psychological tests as screening instruments for neurological dysfunction in a large and varied institutional population.

Method

The Bender Visual-Motor Gestalt Test (BGT) and Symbol Digit Modalities Test (SDMT) were administered to one …