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Fluorescent Probe Development For Fructose Specific Transporters In Cancer, Joseph Fedie
Fluorescent Probe Development For Fructose Specific Transporters In Cancer, Joseph Fedie
Dissertations, Master's Theses and Master's Reports
Carbohydrate transporters or GLUTs of the major facilitator superfamily (MFS) are responsible for transporting sugars into the cell and have been of research interest for decades. Disruptions, mutations, and over-activations of GLUTs have been linked to a number of major diseases including cancer, obesity, and diabetes. Differentiating between transporters is incredibly difficult due to highly conserved structures, and so specific targeting between transporters has proven a complex challenge. GLUTs are highly flexible in their conformations however exactly what will and will not pass through the transporter is ambiguous at best, and many attempt to target these transporters have failed.
In …