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Full-Text Articles in Medicine and Health Sciences
The Development Of A Synthetic Route For A Disubsitituted Diphenylacetylene And Its Conformational Characteristics Upon Coordination To Tungsten: A Prospect For Beta-Sheet Studies, Francis Herman
Senior Theses and Projects
The study of β-sheet mimetics represents an important step in understanding the structural and function of β-sheets. The purpose of this report was to develop a β-sheet mimetic through a diphenylacetylene backbone, coordinate the complex to tungsten and determine the structural and conformational characteristics of the complex. In order to characterize the different compounds ESI-MS, 1HNMR, COSY NMR, NOESY NMR, and ROESY NMR were employed. The diphenylacetylene backbone contained two phenyl substituents with a peptide chain of two amino acids. The β-sheet mimetic 1 was successfully synthesized utilizing peptide coupling reactions and a Sonogashira coupling reaction. Previous research by …
Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague
Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague
Senior Theses and Projects
Previous research within the Curran group has demonstrated that ferrocene may be used as an organometallic constraint to induce the formation of α-helices in short peptides which traditionally possess undefined conformations. Through strategic placement of lysine residues at the i and i+3 positions within the peptide, such a constraint was accomplished via the crosslinking of the lysine side chains to ferrocene dicarboxylic acid chloride in solution phase synthesis. The aim of this work was to develop a method for solid phase peptide synthesis (SPPS) for the synthesis of these ferrocene-constrained helices. In particular, we seek to develop a method in …