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Identification Of Human Postnatal Progenitor Cells With Multifaceted Regenerative Functions, Tyler T. Cooper

Electronic Thesis and Dissertation Repository

Regenerative medicine is a multidisciplinary effort to regenerate or replace a deficiency of functional cells/tissues, such as deteriorated vasculature in cardiovascular pathologies or depleted -cell mass in diabetes. The transplantation of pro-regenerative progenitor cell populations has demonstrated therapeutic benefits in pre-clinical models, although translation to clinical efficacy is limited by the paradoxical balance between cell expansion ex vivo and loss of regenerative functions in vivo. Herein, this thesis encompasses two distinct approaches to circumvent translational deficiencies; 1) prevention of hematopoietic progenitor cell differentiation during ex vivo expansion and 2) utilizing the secretome of pancreas-derived multipotent stromal cell as a …