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Full-Text Articles in Physiology
Genetic And Maternal Effects On Valproic Acid Teratogenesis In C57bl/6j And Dba/2j Mice, Chris Downing, Jami Biers, Colin Larson, Alexi Kimball, Hali Wright, Takamasa Ishii, David Gilliam, Thomas Johnson
Genetic And Maternal Effects On Valproic Acid Teratogenesis In C57bl/6j And Dba/2j Mice, Chris Downing, Jami Biers, Colin Larson, Alexi Kimball, Hali Wright, Takamasa Ishii, David Gilliam, Thomas Johnson
SPS Faculty Publications
Valproic acid (VPA) is used worldwide to treat epilepsy, migraine headaches and bipolar disorder. However, VPA is teratogenic and in utero exposure can lead to congenital malformations. Using inbred C57BL/6J (B6) and DBA/2J (D2) mice, we asked whether genetic variation could play a role in susceptibility to VPA teratogenesis. While B6 fetuses were more susceptible than D2 fetuses to digit and vertebral malformations, D2 fetuses were more susceptible to rib malformations. In a reciprocal cross between B6 and D2, genetically identical F1 mice carried in a B6 mother had a greater percentage of vertebral malformations following prenatal VPA exposure than …