Molecular, Genetic, and Biochemical Nutrition Commons^™

The Effect Of Vitamin D3 Supplementation On Advanced Glycation End Products, (Ages) And Soluble Receptor, (Srage) In African Americans And Hispanics With Type 2 Diabetes And Vitamin D Insufficiency/Deficiency, Justina Serwaah Owusu

FIU Electronic Theses and Dissertations

There is a high burden of diabetes and its related complications globally. Advanced Glycation End Products (AGEs) and their receptors have been implicated in complications and mortality related to type 2 diabetes (T2D). Vitamin D deficiency, prevalent in persons with T2D, increases oxidative stress and inflammation that promotes the formation of AGEs.

This study assessed the relationship between sRAGE and AGEs and risk of cardiovascular diseases (CVD) and the effect of vitamin D3 supplementation on levels of AGEs and soluble receptor (sRAGE) in adults with hypovitaminosis D. African Americans and Hispanics (n=64) were recruited in Miami and were supplemented with …

Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms In Relation To The Risk Of Type 2 Diabetes In Three Ethnicities, Ling Xu

FIU Electronic Theses and Dissertations

Type 2 Diabetes (T2D) disproportionally affects ethnic minorities in the United States. The development of T2D involves complex interaction between environmental factors and genetic predisposition. The genetic associations of six single nucleotide polymorphisms (SNPs) in TCF7L2 gene with the risk of T2D were evaluated in three high risk minority populations: Cuban Americans, Haitian Americans, and African Americans. For Cuban Americans, four SNPs (rs7901695, rs4506565, rs7903146 and rs11225537) were significantly associated with the risk of T2D after multivariable adjustment (p=0.018, p=0.016, p=0.014, and p=0.0008, respectively). Among controls, risk allele carriers of SNPs rs7901695, rs4506565 and rs7903146 had significantly higher fasting glucose …