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Full-Text Articles in Molecular and Cellular Neuroscience
Neuromuscular Junction Development In The Cutaneous Pectoris Muscle Of Rana Catesbeiana, Diana Linden, Susan Jerian, Michael Letinsky
Neuromuscular Junction Development In The Cutaneous Pectoris Muscle Of Rana Catesbeiana, Diana Linden, Susan Jerian, Michael Letinsky
Diana Linden
Synaptic specializations were studied in the developing cutaneous pectoris muscle of Rana catesbeiana tadpoles and froglets to correlate nerve terminal morphology (by light and electron microscopy), accumulation of acetylcholine receptors, and the ability of the muscle to contract following nerve stimulation. This correlated approach was used to determine the developmental timing and possible causal relationship of events in nerve and muscle maturation at the neuromuscular junction. Initially, the cutaneous pectoris nerve trunk was present in the undifferentiated presumptive cutaneous pectoris mesenchyme, prior to muscle maturation. At stage XII when the muscle was first able to contract weakly in response to …
Correlated Muscle And Nerve Development In The Bullfrog Cutaneous Pectoris, Diana Linden, Michael Letinsky
Correlated Muscle And Nerve Development In The Bullfrog Cutaneous Pectoris, Diana Linden, Michael Letinsky
Diana Linden
The development of the cutaneous pectoris muscle was studied and compared with the differentiation of its peripheral nerve in bullfrog (Rana catesbeiana) tadpoles and frogs by light and electron microscopic techniques. This muscle preparation was chosen for this study because it possesses a number of advantages for (and has become a model system for) the study of correlated nerve-muscle development. At the earliest stage examined (stage XI) the presumptive muscle did not contain any contractile or morphologically distinguishable myotubes, but was contacted by the well-defined cutaneous pectoris nerve trunk. Myotubes were present at stage XII, the same time that nerve-associated …