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Full-Text Articles in Developmental Neuroscience
Attentional Dysfunction In Schizophrenia: The Effects Of Dual Orexin Receptor Blockade On An Nmda Receptor Hypofunction Model, Paige Little
Attentional Dysfunction In Schizophrenia: The Effects Of Dual Orexin Receptor Blockade On An Nmda Receptor Hypofunction Model, Paige Little
Undergraduate Honors Theses
Hypofunctionality at the N-Methyl-D-aspartic acid receptor (NMDAR) is a commonly used model of the neurodevelopmental disorder schizophrenia due to the complex circuitry changes that follow NMDAR blockade. While these animal models are very popular for modeling the cognitive deficits seen in schizophrenia, actual treatments for this disorder remain sparse. Orexins (hypocretins) are neuropeptides that are capable of modulating activity along pathways relevant to attention, but are rarely tested for their efficacy in attenuating attentional dysfunction. This study was conducted to determine if systemic administration of the dual orexin receptor antagonist filorexant (MK-6096) was able to attenuate sustained attentional dysfunction induced …