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Articles 1 - 4 of 4
Full-Text Articles in Developmental Neuroscience
The Impact Of Race And Affect On Infant Visual Attention To Faces, Emily Kathryn Grimes
The Impact Of Race And Affect On Infant Visual Attention To Faces, Emily Kathryn Grimes
Chancellor’s Honors Program Projects
No abstract provided.
Circadian Rhythmicity And Neurodevelopment Of Disco And Grim Mutations In Drosophila Melanogaster, John Patrick Story
Circadian Rhythmicity And Neurodevelopment Of Disco And Grim Mutations In Drosophila Melanogaster, John Patrick Story
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
The death gene grim and its pathway for apoptosis has been studied extensively in Drosophila Melanogaster. The effects of grim mutations on circadian neurodevelopment and locomotor assays have yet to be investigated. Mutations in the gene disconnected (disco) has been shown to disrupt the normal development of the circadian circuitry, specifically the small ventro-lateral neurons (s-LNv’s). Which has shown to severely decrease rhythmicity during free-running periods. Alternatively, we have observed an increase in rhythmicity during free-running periods in grim mutations. Our goal is to investigate the neurodevelopment of the circadian circuitry and their associated locomotor activities in these Drosophila mutations.
Pigment Dispersing Factor: Transcriptional Regulation And Its Role In Metabolism In Drosophila Melanogaster, Sudershana Nair
Pigment Dispersing Factor: Transcriptional Regulation And Its Role In Metabolism In Drosophila Melanogaster, Sudershana Nair
Doctoral Dissertations
Almost all living organisms have circadian clocks coordinating physiology and behavior, and an innate molecular clock drives rhythmic changes by integrating environmental and metabolic stimuli to generate 24 hour timing. Drosophila melanogaster has proved to be an excellent model organism with a well-characterized circadian clock and the neural circuits underlying clock have been intensely investigated. The neuropeptide pigment-dispersing factor (PDF) plays an essential role in maintaining circadian rhythmicity and synchronizes circadian clock neurons. However, the regulation of Pdf has been a black box with no known protein identified that directly regulates it, and its role in metabolism hasn’t been looked …
Nuclear Receptors In Ecdysone-Mediated Programmed Cell Death In Drosophila Melanogaster, Ritika Sehgal
Nuclear Receptors In Ecdysone-Mediated Programmed Cell Death In Drosophila Melanogaster, Ritika Sehgal
Masters Theses
The steroid hormone ecdysone plays vital roles during Drosophila development. Pulses of 20E during Drosophila life cycle function as temporal cues, signaling the onset of metamorphic processes, including the stage specific programmed cell death of larval tissues. Ecdysone is the critical developmental cue orchestrating the metamorphic reformation of CNS, resulting in the formation of adult-specific neural circuitry. Ecdysone signaling is transduced by a heterodimeric receptor complex formed between two nuclear receptors: EcR and Ultraspiracle (USP). There are 18 nuclear receptors known in Drosophila and EcR is the only receptor whose functions in neuronal PCD have been well recognized. Therefore, the …