Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Computational Neuroscience
Energy As A Limiting Factor In Neuronal Seizure Control: A Mathematical Model, Sophia E. Epstein
Energy As A Limiting Factor In Neuronal Seizure Control: A Mathematical Model, Sophia E. Epstein
CMC Senior Theses
The majority of seizures are self-limiting. Within a few minutes, the observed neuronal synchrony and deviant dynamics of a tonic-clonic or generalized seizure often terminate. However, a small epilesia partialis continua can occur for years. The mechanisms that regulate subcortical activity of neuronal firing and seizure control are poorly understood. Published studies, however, through PET scans, ketogenic treatments, and in vivo mouse experiments, observe hypermetabolism followed by metabolic suppression. These observations indicate that energy can play a key role in mediating seizure dynamics. In this research, I seek to explore this hypothesis and propose a mathematical framework to model how …