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Full-Text Articles in Neuroscience and Neurobiology

High Fat Diet & Social Isolation: Interactive Effects On Pain, Cognition, & Neuroinflammation, Ian M. Campuzano Aug 2024

High Fat Diet & Social Isolation: Interactive Effects On Pain, Cognition, & Neuroinflammation, Ian M. Campuzano

Research Psychology Theses

Prior research has established a role for both social isolation and exposure to high fat Western diets in altering a range of behaviors from reduced memory performance to increased depression-like behaviors. The present study scrutinizes the interplay among these variables during the peri-adolescent developmental phase, utilizing Long-Evans rats as the experimental model. Our overarching hypothesis is that rats exposed to either social isolation, a high-fat diet, or both will result in heightened pain sensitivity, diminished cognitive flexibility, and increased neuroinflammatory responses within brain regions implicated in sociability, cognition, memory, and pain processing. Behavioral flexibility will be assessed using a maze-based …


Nmda Receptor Inhibition On Rodent Optimal Decision-Making In The Diminishing Returns Task, Seth Foust Aug 2023

Nmda Receptor Inhibition On Rodent Optimal Decision-Making In The Diminishing Returns Task, Seth Foust

Research Psychology Theses

There has been growing interest in using N-methyl-D-aspartate (NMDA) receptor antagonists as treatments for mood disorders, but there is still much to learn about their cognitive effects. Research shows NMDA receptors can affect decision-making, and the antagonist MK-801 has had varying effects in rodents. Specifically, some have reported impairments in working memory while foraging behaviors remained intact, while others have demonstrated changes in choice behavior related to delay or risk in behavior tasks. We investigated the role of NMDA receptors in the specific paradigm of optimal decision-making to further confirm MK-801’s effects and to explore whether inhibiting NMDA receptors alters …


Creating Project Contrast: A Video Game Exploring Consciousness And Qualia, Pierce Papke May 2023

Creating Project Contrast: A Video Game Exploring Consciousness And Qualia, Pierce Papke

Honors Projects

Project Contrast is a video game that explores how the unique traits inherent to video games might engage reflective player responses to qualitative experience. Project Contrast does this through suspension of disbelief, avatar projection, presence, player agency in storytelling, visual perception, functional gameplay, and art. Considering the difficulty in researching qualitative experience due to its subjectivity and circular explanations, I created Project Contrast not to analyze qualia, though that was my original hope. I instead created Project Contrast as an avenue for player self-reflection and learning about qualitative experience. While video games might be just code and art on a …


Social Creatures: The Impact Of Solitary Confinement On Psychophysiological Health And How Inmates Percieve Their Humanity And Social Well-Being, Julia Austin May 2023

Social Creatures: The Impact Of Solitary Confinement On Psychophysiological Health And How Inmates Percieve Their Humanity And Social Well-Being, Julia Austin

Honors Projects

This paper will define and examine the use of solitary confinement within the United States prison system and review its mental, physical, and social impacts. As social creatures, human mental and physical well-being depends on meaningful social interactions absent in segregation units. As it currently stands, vulnerable populations, including racial minorities, LGBTQIA+ individuals, and those with developmental disabilities or psychological disorders, are at risk of irrevocable harm and abuse within these facilities from staff as well as other inmates. With a rotating 80,000 inmates held in solitary confinement every day, the current structure of the prison system deemphasizes rehabilitation and …


How Music Therapy Effects The Traumatized Brain: Neurorehabilitation For Posttraumatic Stress Disorder Through Music Therapy, Jordan Winter Payne Jun 2019

How Music Therapy Effects The Traumatized Brain: Neurorehabilitation For Posttraumatic Stress Disorder Through Music Therapy, Jordan Winter Payne

Honors Projects

This review discusses the neurological components of posttraumatic stress disorder (PTSD) and how both structures and processes in the brain are altered in individuals with the disorder, specifically the neural network that includes the prefrontal cortex, the hippocampus, and the amygdala. This impacts awareness and responsiveness to stimuli. After examining these aspects, invasive and non-invasive treatment approaches are examined, with a specific emphasis on the treatment approach of music therapy. Musical stimuli are processed in many areas of the brain, so it has therapeutic potential for modulating neurological changes. Music therapy applies music clinically to address a variety of goals …


The Effects Of Arginine Vasopressin On Maternal Behavior And Aggression In Peromyscus Californicus Mothers, Nathaniel Ng Jun 2015

The Effects Of Arginine Vasopressin On Maternal Behavior And Aggression In Peromyscus Californicus Mothers, Nathaniel Ng

Honors Projects

Research studies since the 1950s have shown that a chemical within the brain called arginine vasopressin (AVP) is associated with the modulation of many different social behaviors in mammals. Some of these behaviors are related to parenting, such as parental care initiation, aggression, social recognition, depression and anxiety. Understanding the physiology behind AVP regulation could allow for the creation of new therapies for treating human social disorders, such as using an AVP receptor antagonist to attenuate anxiety. This project examines how neural injections of AVP and an AVP receptor antagonist affect both maternal care and aggression in female Peromyscus californicus …