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Full-Text Articles in Virology
A Common Mechanism Links Epstein‐Barr Virus Infections And Autoimmune Diseases, Luwen Zhang
A Common Mechanism Links Epstein‐Barr Virus Infections And Autoimmune Diseases, Luwen Zhang
Nebraska Center for Virology: Faculty Publications
Epstein‐Barr virus (EBV) infection is associated with a variety of the autoimmune diseases. There is apparently no unified model for the role of EBV in autoimmune diseases. In this article, the development of autoimmune diseases is proposed as a simple two‐step process: specific autoimmune initiators may cause irreversible changes to genetic materials that increase autoimmune risks, and autoimmune promoters promote autoimmune disease formation once cells are susceptible to autoimmunity. EBV has several types of latencies including type III latency with higher proliferation potential. EBV could serve as autoimmune initiators for some autoimmune diseases. At the same time, EBV may play …
Multiple Signal Transducers And Activators Of Transcription Are Induced By Ebv Lmp-1, Luwen Zhang, Ke Hong, Jun Zhang, Joseph S. Pagano
Multiple Signal Transducers And Activators Of Transcription Are Induced By Ebv Lmp-1, Luwen Zhang, Ke Hong, Jun Zhang, Joseph S. Pagano
Nebraska Center for Virology: Faculty Publications
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) is required for EBV immortalization of primary B cells in vitro. Signal transducers and activators of transcription (STATs) play a pivotal role in the initiation and maintenance of certain cancers. STAT proteins, especially STAT-1, -3, and -5, are persistently tyrosine phosphorylated or activated in many cancers. We show here that EBV-infected type III latency cells, in which the EBV oncoprotein, LMP-1 is expressed, express high levels of four STATs (STAT-1, -2, -3, and -5A) and that LMP-1 is responsible for the induction of three (STAT-1, -2, and -3). In addition, the C-terminal …
Interferon Regulatory Factor 7: A Key Cellular Mediator Of Lmp-1 In Ebv Latency And Transformation, Luwen Zhang, Joseph S. Pagano
Interferon Regulatory Factor 7: A Key Cellular Mediator Of Lmp-1 In Ebv Latency And Transformation, Luwen Zhang, Joseph S. Pagano
Nebraska Center for Virology: Faculty Publications
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein–Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.