Laboratory and Basic Science Research Commons^™

Environmental Issues For The 21st Century And Their Impact On Human Health, Richard B. Philp

Richard B. Philp

This book (see contents attached) is now available from the author on CD

Myotonia Congenita, Christoph Lossin, Alfred George

Christoph Lossin, Ph.D.

Myotonia is a symptom of many different acquired and genetic muscular conditions that impair the relaxation phase of muscular contraction. Myotonia congenital is a specific inherited disorder of muscle membrane hyperexcitability caused by reduced sarcolemmal chloride conductance due to mutations invCLCN1, the gene coding for the main skeletal muscle chloride channel ClC-1.The disorder may be transmitted as either an autosomal-dominant or recessive trait with close to 130 currently known mutations. Although this is a rare disorder, elucidation of the pathophysiology underlying myotonia congenital established the importance of sarcolemmal chloride conductance in the control of muscle excitability and demonstrated the first …

Preparative Separation Of Pyrrolizidine Alkaloids By High-Speed Counter-Current Chromatography, Roland A. Cooper, Rion J. Bowers, Carla J. Beckham, Ryan J. Huxtable

Roland A. Cooper