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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
Proteins Of Bartonella Bacilliformis:Candidates For Vaccine Development, Cesar Henriquez-Camocho, Palmira Ventosilla, Michael F. Minnick, Joaquim Ruiz, Ciro Maguina
Proteins Of Bartonella Bacilliformis:Candidates For Vaccine Development, Cesar Henriquez-Camocho, Palmira Ventosilla, Michael F. Minnick, Joaquim Ruiz, Ciro Maguina
Biological Sciences Faculty Publications
Bartonella bacilliformis is the etiologic agent of Carrion's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.