Biology Commons^™

Exploring The Biological Function Of Carboxypeptidase O: Analysis Of Expression And Association With Chylomicrons And Lipid Droplets, Erika Bauza Nowotny

Master's Theses

Carboxypeptidase O (CPO) is a membrane-bound peptidase that cleaves acidic and polar C-terminal amino acids of peptides; however, its biological function remains unknown. CPO is strongly expressed in the small intestine, where it has been proposed to participate in digestion events at the brush border by extracellular cleavage of dietary peptides. At the subcellular level, CPO is anchored to the inner leaflet of the endoplasmic reticulum (ER) membrane, where it has been shown to associate with lipid droplets (LDs). The ER membrane also represents the site of iv chylomicron formation, a process that shares many similarities with that of LDs …