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- Autoimmune disease (2)
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Articles 1 - 22 of 22
Full-Text Articles in Life Sciences
Migraine Triggers, Adina Jeidel
Migraine Triggers, Adina Jeidel
The Science Journal of the Lander College of Arts and Sciences
Migraines are a painful and life-interrupting disease which strikes around 23 million Americans every year (Goadsby et al., 2017). Not enough studies have been done to help the public fully understand migraines. Details regarding the causes and pathophysiology of migraines continue to be analyzed by physicians and scientists, as no theory has been fully confirmed regarding a migraine’s concrete path. The goal of this scientific review is to provide an overview for the main triggers of migraines, in reference to recent clinical investigations, and to understand why they might cause patients to be more prone to having a migraine attack …
Is Lsvt Big An Effective And Realistic Treatment Of Parkinson’S Disease?, Elisheva Erlbaum
Is Lsvt Big An Effective And Realistic Treatment Of Parkinson’S Disease?, Elisheva Erlbaum
The Science Journal of the Lander College of Arts and Sciences
Parkinson’s Disease is one of the most common neurological disorders which disrupts the everyday lives of millions of people. This disease is categorized by the loss of dopamine in the brain, specifically the Substantia Nigra. People diagnosed with PD suffer from motor and cognitive impairments. While there is no one treatment which can completely cure the disease, there are many treatments available which can help alleviate symptoms. However, most of the treatments cause many negative side effects. Recently, a new physical therapy treatment, LSVT BIG has begun to show its effects. This revue describes the many factors and treatments of …
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Science Journal of the Lander College of Arts and Sciences
Autoimmune disease refers to a systemic immune response by the body against its own healthy tissue and cells. This results in various non-specific and systemic inflammatory processes that evolve into more than 100 individual diseases. Numerous biological similarities exist between the different pathophysiological pathways, including biochemical cascades and inflammasome mediators. This paper aims to investigate whether contracting one form of autoimmune disease can lead to the development of polyautoimmunity and multiple autoimmune syndrome. Scientists have identified chronic levels of high stress as a contributor to higher levels of C-reactive protein and several immune modulating interleukins, which can lead to both …
Effects Of Soy Isoflavone, Anne Roberts
Effects Of Soy Isoflavone, Anne Roberts
The Science Journal of the Lander College of Arts and Sciences
Soy, which contains a form of phytoestrogen known as isoflavones, impacts the biological activity of humans at all stages. There are many aspects to consider when determining whether soy is beneficial. Since the hormone estrogen plays a significant role in maintaining the biochemical and homeostatic conditions of an individual, it follows that the disruption of estrogenic levels can be detrimental. There are many hormone- dependent diseases that can be linked to one’s diet, and the possibility of utilizing phytoestrogens, such as soy, to prevent or control hormonal irregularities is compelling. This paper explores the effects that phytoestrogens, specifically soy, can …
Rapamycin And Metformin In Treating Covid-19, Avrohom Karp
Rapamycin And Metformin In Treating Covid-19, Avrohom Karp
The Science Journal of the Lander College of Arts and Sciences
The SARS-CoV-2 virus has spread rapidly, resulting in a global pandemic. There is a great need for an effective drug cocktail therapy to combat Acute Respiratory Distress Syndrome (ARDS), a major cause of death due to COVID-19. The two drugs examined are metformin, an antidiabetic medication, and rapamycin. Rapamycin is often prescribed for transplant patients as it has an immunosuppressive effect. The aim of the investigation was to determine the efficacy of metformin and rapamycin in treating COVID-19, and to examine what an effective protocol would look like. These two drugs both inhibit mTOR and can reduce the body’s auto-immune …
Do People With Hashimoto’S Disease Need A Thyroidectomy?, Miriam Minkowitz
Do People With Hashimoto’S Disease Need A Thyroidectomy?, Miriam Minkowitz
The Science Journal of the Lander College of Arts and Sciences
Hashimoto’s Thyroiditis (HT) is one of the most common autoimmune diseases (Hiromatsu et al. 2013 p.13). It primarily affects the thyroid gland. The thyroid gland influences growth and regulates the body’s metabolism by manipulating hormonal levels. Hashimoto’s thyroiditis affects thyroid function through mechanisms that cause the hormone levels to become dysregulated. The standard therapy for Hashimoto’s thyroiditis is hormone replacement. This approach helps most patients by regulating their thyroid hormones, though there are some individuals who fail treatment. Untreatable patients are plagued with weight gain, sleep disturbances, and other symptoms. Certain factors in thyroid disease may cause various secondary complications …
Full Issue: Volume 14, Number 2, Spring 2021
Full Issue: Volume 14, Number 2, Spring 2021
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 14, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2021.
Lupus And The Effects On Pregnancy, Elana Eisenreich
Lupus And The Effects On Pregnancy, Elana Eisenreich
The Science Journal of the Lander College of Arts and Sciences
Systemic Lupus Erythematosus is a disease that manifests in many different ways. The cause of lupus still remains elusive. However, many of the pathologies associated with the disease as well as the disease process have been described. The pathophysiology of the disease as well as its effects on specific patient groups will be discussed below. More specifically, Systemic Lupus’ effect on pregnancy with current diagnostic and treatment modalities will be the focus of this paper.
What Are The Possible Causes And Effective Therapeutic Approaches Of Preeclampsia?, Adina Hadi
What Are The Possible Causes And Effective Therapeutic Approaches Of Preeclampsia?, Adina Hadi
The Science Journal of the Lander College of Arts and Sciences
Preeclampsia is a complication of pregnancy primarily characterized by hypertension and proteinuria and affects other organs as well. The underlying causes are not yet fully understood. However, it is suggested that angiogenic factors of the placenta, genetic factors, a malfunctioning immune system, and oxidative stress all play a role in causing preeclampsia. Currently, the only definitive cure known for preeclampsia is delivery of the baby. Management of the condition includes taking preventative measures as well as drugs such as labetalol and MgSO4. This paper analyzes mechanisms of preeclampsia and determines the possible causes and most effective ways to manage the …
Enzybiotic Therapy As Treatment For Mrsa, Rachel Finkelstein
Enzybiotic Therapy As Treatment For Mrsa, Rachel Finkelstein
The Science Journal of the Lander College of Arts and Sciences
This paper reviews the antibacterial potential of enzybiotics against Methicillin-resistant Staphylococcus aureus (MRSA). Due to the increasing occurrence of antibiotic resistance, researchers are looking to make use of the natural antibacterial qualities of virus bacteriophages, viral derived lysins, and antimicrobial peptides to fight MRSA infections. The efficacy of bacteriophages, endolysins, and bacteriocins as potential antibacterial agents against MRSA was extensively researched through Touro’s online library database. Each of their mechanisms of action allows them to effectively lyse S. aureus cells, by essentially disrupting the peptidoglycan in the cell wall, causing it to burst. The narrow host range of these antimicrobials …
Dance Training And Delayed Maturation, Shira Heavenrich
Dance Training And Delayed Maturation, Shira Heavenrich
The Science Journal of the Lander College of Arts and Sciences
The physiological effects of early childhood dance training are constantly being explored and adjusted. It was observed that children in training experience a higher than normal percentage of delayed maturation, both in puberty and bone development. It was suggested that the environmental conditions in which dancers practice, such as malnutrition and too much time spent indoors, as well as biological factors, contribute to the hormonal and cellular disruptions responsible for late development. Undernourishment, as is common in dancers, was found to have a direct correlation with reproductive hormone levels, including reduction in gonadotropin- releasing hormone secretion as well as lower …
Developing Approaches Towards The Treatment Of Covid-19, Chana Weis
Developing Approaches Towards The Treatment Of Covid-19, Chana Weis
The Science Journal of the Lander College of Arts and Sciences
In late 2019 a newly identified strain of coronavirus, SARS-CoV-2 emerged, causing a worldwide pandemic of respiratory illness, Covid-19. Covid-19 has drastically transformed the world in numerous ways. The virus is highly contagious and, in some cases, fatal. A successful cure has not yet been discovered and therefore society is urged to take proper precautions to prevent the spread of the potentially fatal virus. This paper analyzes the proper precautions that should be taken as well as the ongoing research that has been done to stop the spread of the virus.
The Role Of Immunotherapy In Treating High-Risk Neuroblastoma, Mollie Raczkowski
The Role Of Immunotherapy In Treating High-Risk Neuroblastoma, Mollie Raczkowski
The Science Journal of the Lander College of Arts and Sciences
Neuroblastoma originates from the cells in the neural crest. High-risk neuroblastoma, patients have poor outcomes even with the multi-step treatment plans, including immunotherapy maintenance treatment. Researchers in developmental biology search for unique antigens in neuroblastoma cells to utilize monoclonal antibodies (mAbs). Currently, GD2 is the most effective antigen that scientists have isolated in the tumor; these anti-GD2 mAbs are administered in the forms of Dinutuximab or Dinutuximab beta to attack the tumor. Monoclonal antibodies are currently administered in neuroblastoma instead of CAR T (that has seen success in curing different types of leukemias) due to the heterogeneity of this tumor. …
Osteoporosis: A Comprehensive Review, Eliyahu Greenberg
Osteoporosis: A Comprehensive Review, Eliyahu Greenberg
The Science Journal of the Lander College of Arts and Sciences
Osteoporosis is a disease of the skeleton that becomes more common with advanced age, especially in postmenopausal women. Osteoporosis increases the risk of fractures, thereby reducing the quality of life for those who suffer from it. Due to the aging population, direct costs resulting from osteoporosis are projected to reach upward of $25 billion per year by 2025. The main pharmaceuticals primarily target osteoclasts. Exercise may be an effective method of preventing osteoporosis, although more research needs to be done. More research should be conducted to explore potential ways to enhance osteoblastic activity as a method to treat and/or reverse …
Understanding Pathophysiology Of Nonsyndromic Autism By Examining And Extrapolating From Syndromic Variants, Alexander Labkowsky
Understanding Pathophysiology Of Nonsyndromic Autism By Examining And Extrapolating From Syndromic Variants, Alexander Labkowsky
The Science Journal of the Lander College of Arts and Sciences
Autism spectrum disorder (ASD) is a broad, heterogeneous neurodevelopmental disorder encompassing a range of presentation and severity. The common characteristics include communication deficits, impaired social skills, dependency on routine, sensitivity to environmental change, and stereotyped behavior (DSM-5, 2013). When ASD is accompanied by a host of other symptoms it is often referred to as syndromic autism. Syndromic autism is usually severe and can usually be traced to deletions or duplications on a specific gene. These monogenic disorders are by definition easier to diagnose and are good candidates for study since specific biological markers can be assessed and tracked. There have …
Full Issue: Volume 15, Number 1, Fall 2021
Full Issue: Volume 15, Number 1, Fall 2021
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 15, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2021.
Etiology And Associations Of Oral And Oropharyngeal Cancer, Aron Yaghar
Etiology And Associations Of Oral And Oropharyngeal Cancer, Aron Yaghar
The Science Journal of the Lander College of Arts and Sciences
This research paper discusses oral cavity cancer, which is one of the 11th most common cancers in the world. According to newer research, some important possible causes include smokeless tobacco, marijuana, and citrus fruits. Some research attributes it to one’s genetic makeup and include exposure to Human Papillomavirus (HPV) and diagnosis of Diabetes mellitus, all in conjunction with one’s age. In this research paper, each of these factors are discussed in depth, and their association with this illness is considered and debated. Review of the literature reveals that the high concentrations of nicotine found in smokeless tobacco products is deleterious …
The Riddle Of The Fetal Allograft, Rachel Tepper
The Riddle Of The Fetal Allograft, Rachel Tepper
The Science Journal of the Lander College of Arts and Sciences
The immunological paradox of nurturing a fetus with paternal antigens poses some perplexing questions. Peter Medawar, an immunologist, asked at a lecture, “How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body?” Researchers have since then struggled to answer this question. The research on this topic has led to a few general hypotheses that try to explain this phenomenon. The downregulation of T cells toward paternal alloantigens is an accepted hypothesis. Another hypothesis discusses the significance of the decidua and its ability to impair dendritic cells, which …
What Common Factors May Influence The Success Of Dental Implant?, Yehuda Taavar
What Common Factors May Influence The Success Of Dental Implant?, Yehuda Taavar
The Science Journal of the Lander College of Arts and Sciences
The aim of this study is to investigate the common factors that may influence the success of dental implants. Addressing these factors may potentially aid experts in the field in delivering dental implants without approaching or decreasing the number of failures. Smoking, diabetes, implant maintenance, age, and implant size have significantly influenced implant success. It is suggested that patients are advised to quit smoking at least one week before surgery to minimize risk factors. Inadequate glycemic control also contributes to periodontal destruction and is associated with the severity of peri-implant complications. However, if patients maintain good glycemic control, dental implants …
Can Robotic Exoskeletons Improve Gait In Ms Patients?, Chana Weinberg
Can Robotic Exoskeletons Improve Gait In Ms Patients?, Chana Weinberg
The Science Journal of the Lander College of Arts and Sciences
Multiple Sclerosis (MS) is a neurological disorder that affects about one million people in the United States. The disease results from an abnormal immune response where T cells damage the myelin sheath in the central nervous system, causing scarring. The lesions can occur in any part of the brain or spinal cord, and thus affects every patient differently. One of the most detrimental effects the disease has on patients’ lives is the decreased ability to walk. There has been research and treatments to manage pain and slow progression of the disease, but little progress has been made to enable MS …
What Is The Safest And Most Effective Method Of Repairing Myelomeningocele?, Matti Klein
What Is The Safest And Most Effective Method Of Repairing Myelomeningocele?, Matti Klein
The Science Journal of the Lander College of Arts and Sciences
Spina bifida is one of the most common NTD’s (neural tube defects) to occur during embryonic development, when the neural tube fails to close properly during neurulation. Myelomeningocele is the most severe form of spina bifida. Characterized by an open posterior neuropore with meninges and parts of the spinal cord protruding from the fetus’s body, it manifests in a variety of physical and neurological symptoms that vary both by the individual and by the state of the lesion. Until the late 1990’s, the standard course of treatment was surgical closure of the lesion at birth, followed by standard protocols and …
What Is The Underlying Cause Of Infantile Colic?, Tamar Itzkowitz
What Is The Underlying Cause Of Infantile Colic?, Tamar Itzkowitz
The Science Journal of the Lander College of Arts and Sciences
Infantile colic (IC) is an important area of current research due to the extreme distress it causes parents and their infants. It is vital that a cause is isolated so that treatment can be found because IC is a risk factor for child abuse. In this paper, two major theories were posed to elucidate the underlying cause of IC—the gastrointestinal model and the neurological model. The gastrointestinal model suggests that IC stems from issues such as an immature gut. The neurological model suggests that infantile migraines are the causative agents of IC. Both theories supply correlational evidence but are subject …