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Compensatory Changes In Cyp Expression In Three Different Toxicology Mouse Models: Car-Null, Cyp3a-Null, And Cyp2b9/10/13-Null Mice, Ramiya Kumar, Linda C. Mota, Elizabeth J. Litoff, John P. Rooney, W. Tyler Boswell, Elliott Courter, Charles M. Henderson, Juan P. Hernandez, J. Christopher Corton, David D. Moore, William S. Baldwin
Compensatory Changes In Cyp Expression In Three Different Toxicology Mouse Models: Car-Null, Cyp3a-Null, And Cyp2b9/10/13-Null Mice, Ramiya Kumar, Linda C. Mota, Elizabeth J. Litoff, John P. Rooney, W. Tyler Boswell, Elliott Courter, Charles M. Henderson, Juan P. Hernandez, J. Christopher Corton, David D. Moore, William S. Baldwin
Publications
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes in transcript levels, protein expression, and steroid hydroxylation of several xenobiotic detoxifying CYPs in constitutive androstane receptor (CAR)-null and two CYP-null mouse models that have subfamily members regulated by CAR; the Cyp3a-null and a newly described Cyp2b9/10/13-null mouse model. Compensatory changes in CYP expression that occur in these models may also occur in polymorphic humans, or may complicate interpretation of ADME studies performed …