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Full-Text Articles in Life Sciences

Scientist In The Making: [Dr. Alice Bendix Gottlieb], Fulvio Bardossi, Judith N. Schwartz Oct 1981

Scientist In The Making: [Dr. Alice Bendix Gottlieb], Fulvio Bardossi, Judith N. Schwartz

Rockefeller University Research Profiles

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.


Structures: [Dr. Emil C. Gotschlich], Fulvio Bardossi, Judith N. Schwartz Apr 1981

Structures: [Dr. Emil C. Gotschlich], Fulvio Bardossi, Judith N. Schwartz

Rockefeller University Research Profiles

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.


The Membrane Polypeptides Of The Vacuolar System: Composition And Recycling, William A. Muller Jan 1981

The Membrane Polypeptides Of The Vacuolar System: Composition And Recycling, William A. Muller

Student Theses and Dissertations

A method has been developed to deliver an iodinating system into the confines of the phagolysosome, allowing us to study the nature of the phagolysosomal membrane. Lactoperoxidase (LPO) is covalently coupled to carboxylated latex spheres (LPO-latex) in a stable enzymatically active form. The addition of LPO-Iatex to cultured macrophages leads to their rapid attachment, ingestion, and enclosure in a plasma membranederived phagocytic vacuole. These organelles rapidly fuse with preexisting lysosomes and are converted to phagolysosomes (PL) that demonstrate both acid phosphatase and lactoperoxidase activities. The exposure of LPO-Iatex containing cells to 125-- and an extracellular peroxide-generating system, glucose oxidase-glucose, at …


On The Eigentheory Of Operators Which Exhibit A Slow Variation, Lawrence Sirovich, Bruce Knight Jan 1981

On The Eigentheory Of Operators Which Exhibit A Slow Variation, Lawrence Sirovich, Bruce Knight

Knight Laboratory

No abstract provided.


Transcriptional And Translational Products Of Avian Erythroblastosis And Avian Myeloblastosis Viruses, Steven Mathias Anderson Jan 1981

Transcriptional And Translational Products Of Avian Erythroblastosis And Avian Myeloblastosis Viruses, Steven Mathias Anderson

Student Theses and Dissertations

The transcription and translation products of two avian acute leukemia viruses, avian erythroblastosisvirus (AEV) and avian myeloblastosisvirus (AMV) , were examined. AEV is defective in virus replication and requires the presence of a helper virus to produce infectious progeny. AEV-transformed nonproducer cells were found to contain no proteins participating in virus replication. Instead, nonproducer cells were found to contain a 75,000 Dalton gag-related polyprotein (p75) which contains the p19 region of the gag gene at its amino terminus. Two-dimensional tryptic peptide mapping indicated that p75 contained novel peptides in addition to those derived from p19. p75 was found to be …


Promoters And Heterogeneous 5' Termini Of The Messenger Rnas Of Adenovirus 2, Carl Chester Baker Jan 1981

Promoters And Heterogeneous 5' Termini Of The Messenger Rnas Of Adenovirus 2, Carl Chester Baker

Student Theses and Dissertations

Adenovirus-2 messenger RNAs are transcribed from nine separate transcription units which function during early, intermediate and late stages of infection. I have sequenced capped 5* termini of messenger RNAs from each of these transcription units, and located the templates for each capped terminus in the sequence of the Ad2 genome. These results define the putative initiation sites and promoters for all major Ad2 transcripts. By comparing the termini and promoter DNA sequences I conclude that seven of nine initiation sites including Ela, Elb, PIX, major late, EIII, EIV and the late form of region Ila mRNA have clearly defined TATA …


Composition And Dynamics Of The Plasma Membrane Of Entamoeba Histolytica, Stephen Blaine Aley Jan 1981

Composition And Dynamics Of The Plasma Membrane Of Entamoeba Histolytica, Stephen Blaine Aley

Student Theses and Dissertations

The study of the parasitic protozoa presents a multifaceted opportunity for biological research. These organisms are eucaryotic cells with many of the biological systems described in higher eucaryotic cells. However, they are adapted to highly specialized environments, invoking sometimes subtle and often unique variations of these biological systems. More important, an understanding of the biology of the parasite and the differences between the parasite and mammalian cells can be invaluable in the development of pharmacological and immunological methods of control of the parasite. The subject of this thesis, the parasitic amoeba Entamoeba hystolytica, is an ideal subject for such research. …


Characterization Of Phagosome-Lysosome Fusion In Macrophages, Margaret Carol Kielian Jan 1981

Characterization Of Phagosome-Lysosome Fusion In Macrophages, Margaret Carol Kielian

Student Theses and Dissertations

Several approaches were used to study the determinants of phagosome-lysosome {P-L} fusion in intact mouse macrophages. Lysosomes were labeled with the fluorescent vital dye acridine orange and the rate and extent of their fusion with yeast-containing phagosomes was monitored by fluorescence microscopy. Fusion was also assayed by electron microscopy, using horseradish peroxidase or thorium dioxide as markers for secondary lysosomes. Good agreement was found with results obtained from vitally-stained cells, thin section samples using an enzymatic marker, and thorium dioxide-labeled samples evaluated by stereology.


Particles Of Light, Webs Of Interaction: [Dr. Floyd Ratliff], Fulvio Bardossi, Judith N. Schwartz Jan 1981

Particles Of Light, Webs Of Interaction: [Dr. Floyd Ratliff], Fulvio Bardossi, Judith N. Schwartz

Rockefeller University Research Profiles

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.