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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Attribute Relationships: An Impediment In Automating Schema Integration, Amit P. Sheth, Sunit K. Gala
Attribute Relationships: An Impediment In Automating Schema Integration, Amit P. Sheth, Sunit K. Gala
Kno.e.sis Publications
Success in schema integration depends on understanding the semantics of schema components (e.g., entity sets, relationship sets, attributes), and the ability to capture and reason about these semantics. An important objective of our work on schema integration is to automate the reasoning as much as possible, and when not possible, depend on the human input and guidance. A key results of comparing the semantics associated with schema objects is that of determining attribute relationship. Once attribute relationships are determined, the task of object class(e.g., entity sets and relationship sets) integration becomes simpler and can e automated to a great extent. …
Significance Of Premature Stop Codons In Env Of Simian Immunodeficiency Virus, Toshiaki Kodama, Dawn P. Wooley, Yathirajulu M. Naidu, Harry W. Kestler Iii, Muthiah D. Daniel, Yen Li, Ronald C. Desrosiers
Significance Of Premature Stop Codons In Env Of Simian Immunodeficiency Virus, Toshiaki Kodama, Dawn P. Wooley, Yathirajulu M. Naidu, Harry W. Kestler Iii, Muthiah D. Daniel, Yen Li, Ronald C. Desrosiers
Neuroscience, Cell Biology & Physiology Faculty Publications
The location of the translational termination codon for the transmembrane protein (TMP) varies in three infectious molecular clones of simian immunodeficiency virus from macaques (SIVmac). The SIVmac251 and SIVmac142 infectious clones have premature stop signals that differ in location by one codon; transfection of these DNAs into human HUT-78 cells yielded virus with a truncated TMP (28 to 30 kilodaltons [kDa]). The SIVmac239 infectious clone does not have a premature stop codon in its TMP-coding region. Transfection of HUT-78 cells with this clone initially yielded virus with a full-length TMP (41 kDa). …
Micronuclear Genome Organization In Euplotes Crassus: A Transposonlike Element Is Removed During Macronuclear Development, Scott Everet Baird, Gina M. Fino, Susan L. Tausta, Lawrence A. Klobutcher
Micronuclear Genome Organization In Euplotes Crassus: A Transposonlike Element Is Removed During Macronuclear Development, Scott Everet Baird, Gina M. Fino, Susan L. Tausta, Lawrence A. Klobutcher
Biological Sciences Faculty Publications
After mating, hypotrichous ciliated protozoa transform a set of their micronuclear chromosomes into thousands of short, linear DNA molecules that form the macronuclear genome. To examine micronuclear genome organization in the hypotrich Euplotes crassus, we have analyzed two cloned segments of micronuclear DNA as well as the macronuclear DNA molecules that are derived from them. E. crassus was found to display a number of features characteristic of other hypotrich genomes, including (i) clustering and close spacing of the precursors of macronuclear DNA molecules, (ii) the frequent occurrence of internal eliminated sequences within macronuclear precursors, (iii) overlapping macronuclear precursors, (iv) lack …
Fault Tolerance In A Very Large Database System: A Strawman Analysis, Amit P. Sheth
Fault Tolerance In A Very Large Database System: A Strawman Analysis, Amit P. Sheth
Kno.e.sis Publications
A simple model is used to study the effect of fault-tolerance techniques and system design on system availability. A generic multiprocessor architecture is used that can be configured in different ways to study the effect of system architectures. Important parameters studied are different system architectures and hardware fault-tolerance techniques, mean time to failure of basic components, database size and distribution, interconnect capacity, etc. Quantitative analysis compares the relative effect of different parameter values. Results show that the effect of different parameter values on system availability can be very significant. System architecture, use of hardware fault tolerance (particularly mirroring), and data …
Characterization Of Chromosome Fragmentation In Two Protozoans And Identification Of A Candidate Fragmentation Sequence In Euplotes Crassus, Scott Everet Baird, Lawrence A. Klobutcher
Characterization Of Chromosome Fragmentation In Two Protozoans And Identification Of A Candidate Fragmentation Sequence In Euplotes Crassus, Scott Everet Baird, Lawrence A. Klobutcher
Biological Sciences Faculty Publications
Following the sexual cycle, hypotrichous ciliated protozoans fragment a set of their micronuclear chromosomes to generate the thousands of short, linear DNA molecules present in the transcriptionally active macronucleus. We have used a hybrid selection procedure to examine macronuclear DNA molecules for subtelomeric length heterogeneity to determine whether chromosome fragmentation occurs at unique or multiple sites. The results suggest that multiple, but closely spaced, chromosome fragmentation sites are used by Oxytricha nova. In contrast, Euplotes crassus uses unique chromosome fragmentation sites in a reproducible manner to generate the ends of macronuclear DNA molecules. Additional studies compared DNA sequences in …