Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Prevention Of Silica Urinary Calculi In A Laboratory Animal Model, Royce J. Emerick, Carl J. Schreier, Donghao Lu
Prevention Of Silica Urinary Calculi In A Laboratory Animal Model, Royce J. Emerick, Carl J. Schreier, Donghao Lu
South Dakota Beef Report, 1986
An animal model utilizing Sprague-Dawley rats fed a diet containing 2% of tetraethylorthosilicate (TES) has been used to study urinary conditions and dietary factors preventing silica urinary calculi . The basal TES diet produced approximately a 50% incidence of silica urinary calculi. Supplemental dietary phosphorus and the urinary acidifying agent ammonium chloride greatly reduced the urinary calculi incidence, while supplemental dietary calcium and urine alkalinization with sodium bicarbonate increased the incidence. The protection from silica urinary calculi provided by sodium or ammonium phosphate compounds was found to be independent of their urinary acidifying effects, and the effects of phosphates and …