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In Vitro Influenza Virus-Inhibitory Effects Of A Series Of Germanium- Orsilicon-Centered Polyoxometalates, J. H. Huffman, R. W. Sidwell, Dale L. Barnard, A. Morrison, M. I. Otto, C. L. Hill, R. F. Schinazi
In Vitro Influenza Virus-Inhibitory Effects Of A Series Of Germanium- Orsilicon-Centered Polyoxometalates, J. H. Huffman, R. W. Sidwell, Dale L. Barnard, A. Morrison, M. I. Otto, C. L. Hill, R. F. Schinazi
Animal, Dairy, and Veterinary Science Faculty Publications
A series of germanium- or silicon-centred heteropolytungstates (polyoxometalates) with the Barrel, Keggin or double Keggin structure were evaluated in vitro for their effects against influenza A (IV-A) and B (IV-B) viruses. Their 50% effective concentrations (EC50) against recent isolates of IV-A (H1 N1 ) and IV-B ranged from 0.1 to 7.8 μM; against IV-A (H3N2), the EC50 concentrations were often 10-fold higher. Recent clinical isolates of IV-A were generally more susceptible to these antiviral effects than older, laboratory-adapted strains. These experiments used inhibition of viral CPE in MDCK cells as determined microscopically and by Neutral Red (NR) …