Operations Research, Systems Engineering and Industrial Engineering Commons^™

Studying Pedestrian’S Unmarked Midblock Crossing Behavior On A Multilane Road When Interacting With Autonomous Vehicles Using Virtual Reality, Fengjiao Zou

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This dissertation focuses on the challenge of pedestrian interaction with autonomous vehicles (AVs) at unmarked midblock locations where the right-of-way is unspecified. A virtual reality (VR) simulation was developed to replicate an urban unmarked midblock environment where pedestrians cross a four-lane arterial roadway and interact with AVs. One research goal is to investigate the impact of roadway centerline features (undivided, two-way left-turn lane, and median) and AV operational schemes portrayed through on-vehicle signals (no signal, yellow negotiating indication, and yellow/blue negotiating/no-yield indications) on pedestrian crossing behavior. Results demonstrate that both roadway centerline design features and AV operations and signaling show …

Essays On Perioperative Services Problems In Healthcare, Amogh S. Bhosekar

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One of the critical challenges in healthcare operations management is to efficiently utilize the expensive resources needed while maintaining the quality of care provided. Simulation and optimization methods can be effectively used to provide better healthcare services. This can be achieved by developing models to minimize patient waiting times, minimize healthcare supply chain and logistics costs, and maximize access. In this proposal, we study some of the important problems in healthcare operations management. More specifically, we focus on perioperative services and study scheduling of operating rooms (ORs) and management of necessary resources such as staff, equipment, and surgical instruments. We …

Optimal Global Supply Chain And Warehouse Planning Under Uncertainty, Avnish Kishor Malde

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A manufacturing company's inbound supply chain consists of various processes such as procurement, consolidation, and warehousing. Each of these processes is the focus of a different chapter in this dissertation.

The manufacturer depends on its suppliers to provide the raw materials and parts required to manufacture a finished product. These suppliers can be located locally or overseas with respect to the manufacturer's geographic location. The ordering and transportation lead times are shorter if the supplier is located locally. Just In Time (JIT) or Just In Sequence (JIS) inventory management methods could be practiced by the manufacturer to procure the raw …

Adaptive Design And Flexible Approval Of Clinical Trials, Saeid Delshad Sisi

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Dose-finding clinical trials are among the most critical cornerstones of the healthcare system. In this broad research area, there are many decision making problems that are extremely challenging to address. However, a small improvement may result in significant benefits to the society. Dose-finding clinical trials are extremely expensive and require multiple time-consuming and complicated R&D phases. Despite all the costs and the long time these trials need to conclude (on average over ten years for each new drug/technology), only less than 15\% of these trials successfully end up in a new approved drug entering the market. This problem is even …

Design And Operations Of A New Facility In A Next Generation Logistic System Based On Horizontal Collaboration, Dilhani Marasinghe

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The growing amount of freight combined with systemic inefficiencies are stressing current logistic systems. Including horizontal collaboration in the future could provide significant help but this strategy will require several new types of facilities. The most flexible type of horizontal collaboration, however, required freight routing decisions to be made dynamically, in real time, and based on last minute information. This research explores one new facility type operating in this environment that handles a high throughput of pallets or pallet-like containers. A key design feature is how much storage these facilities should have to better coordinate outbound loads. The approach taken …

A Study Of Scheduling Problems With Sequence Dependent Restrictions And Preferences, Nitin Srinath

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In some applications like fabric dying, semiconductor wafer processing, and flexible manufacturing, the machines being used to process jobs must be set up and serviced frequently. These setup processes and associated setup times between jobs often depend on the jobs and the sequence in which jobs are placed onto machines. That is, the scheduling of jobs on machines must account for the sequence-dependent setup times as well. These setup times can be a major factor in operational costs. In fabric dyeing processes, the sequence in which jobs are processed is also important for quality, i.e., there is a strong preference …

Double Tolerance Design In Stochastic Production Environments, Di Liu

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In a production process, it is impossible to produce parts with exact specifications. Thus, specific ranges, i.e., tolerances, are commonly employed to define intervals for the quality characteristics of conforming products (Wu & Tang (1998)). Usually, a product is deemed conforming when the measurement of the quality characteristic falls within the tolerance. If the measurement falls outside the tolerance, the product is nonconforming and it can be reworked or scrapped. One of the important engineering problems commonly faced by practitioners is to determine optimal engineering tolerances to be used in production. As a result, tolerance design techniques are widely used …

Design And Analysis Of Efficient Freight Transportation Networks In A Collaborative Logistics Environment, Vishal Badyal

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The increase in total freight volumes, reducing volume per freight unit, and delivery deadlines have increased the burden on freight transportation systems of today. With the evolution of freight demand trends, there also needs to be an evolution in the freight distribution processes. Today's freight transportation processes have a lot of inefficiencies that could be streamlined, thus preventing concerns like increased operational costs, road congestion, and environmental degradation. Collaborative logistics is one of the approaches where supply chain partners collaborate horizontally or/and vertically to create a centralized network that is more efficient and serves towards a common goal or objective. …

Examining The Impact Of Design Features Of Electronic Health Records Patient Portals On The Usability And Information Communication For Shared Decision Making, Rong Yin

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The use of the Electronic Health Records (EHR) patient portal has been shown to be effective in generating positive outcomes in patients’ healthcare, improving patient engagement and patient-provider communication. Government legislation also required proof of its meaningful use among patients by healthcare providers. Typical patient portals also include features such as health information and patient education materials. However, little research has examined the specific use of patient portals related to individuals with specific diseases such as inflammatory bowel diseases (IBDs). IBDs are life-long, not curable, chronic diseases that can impact the whole population. Individuals with IBDs may have higher needs …

Selected Interdiction Games With Uncertain, Risk-Averse, And Simultaneous Play Considerations, Di H. Nguyen

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This dissertation examines two network interdiction problems: a shortest-path interdiction problem under uncertainty and a network interdiction problem in a simultaneous game. Both problems happen in two stages over a directed network, and involve a leader and a follower who have opposing interests.

In the first problem, the leader acts first to lengthen a subset of arcs, and a follower acts second to select a shortest path across the network. The cost for a follower’s arc consists of a base cost if the arc is not interdicted, plus an additional cost that is incurred if the arc is interdicted. The …

Multistage Stochastic Programming: Algorithms, Modelling And Applications, Murwan Siddig

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This dissertation comprises four di˙erent topics related to multistage stochastic program-ming (MSP) algorithms, modeling, and applications.

First, we extend the adaptive partition-based approach for solving two-stage stochastic programs with a fixed recourse matrix and a fixed cost vector to the MSP setting, where the stochastic process is assumed to be stage-wise independent. The proposed algorithms integrate the adaptive partition-based strategy with a popular approach for solving multistage stochastic programs, the stochastic dual dynamic programming (SDDP) algorithm, according to two main strategies. These two strategies are distinct from each other in the manner by which they refine the partitions during the …

Nursing Interruption Dynamics: The Impact Of Work System Factors, Yushi Yang

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Interruptions occur frequently in healthcare work systems. Hands-free Communication Devices (HCDs) were implemented in healthcare work systems to support the interruption process. However, from a sociotechnical systems perspective, HCDs may introduce new complications and unintended consequences to the work system. Research gaps exist in investigating the complexity of HCD interruptions in the real-world context. This dissertation aims to understand HCD interruption dynamics in the nursing work systems, using qualitative research methods. The first study examined the major differences between face-to-face and HCD-mediated interruptions, based on 30 hours of field observations in the acute care setting. Three major differences included: (1) …

Integrating Visual Mnemonics And Input Feedback With Passphrases To Improve The Usability And Security Of Digital Authentication, Kevin Juang

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The need for both usable and secure authentication is more pronounced than ever before. Security researchers and professionals will need to have a deep understanding of human factors to address these issues. Due to their ubiquity, recoverability, and low barrier of entry, passwords remain the most common means of digital authentication. However, fundamental human nature dictates that it is exceedingly difficult for people to generate secure passwords on their own. System-generated random passwords can be secure but are often unusable, which is why most passwords are still created by humans. We developed a simple system for automatically generating mnemonic phrases …

Two-Stage Methodology For Managing And Controlling Material Flow Between Multiple Construction Projects, Fatmah Almazkoor

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There is a strong connection between managing and controlling material flow in a supply chain and its performance. While this is true in all supply chains, it is particularly true in the construction supply chain (CSC) where the total demand for parts is finite, the storage space available can be small, and the variability in consumption is high. On the other hand, effectively controlling the CSC can have a significant impact on controlling risk and buffering their impact so that projects stay on schedule and within budget. Currently, a common control of the CSC is with a push-based material ordering …

Strategies To Improve The Efficiency Of Emergency Medical Service (Ems) Systems Under More Realistic Conditions, Kanchala Sudtachat

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Emergency medical service (EMS) systems provide medical care to pre-hospital patients who need rapid response and transportation. This dissertation proposes a new realistic approach for EMS systems in two major focuses: multiple unit dispatching and relocation strategies. This work makes recommendations for multiple-unit dispatch to multiple call priorities based on simulation optimization and heuristics. The objective is to maximize the expected survival rate. Simulation models are proposed to determine the optimization. A heuristic algorithm is developed for large-scale problems. Numerical results show that dispatching while considering call priorities, rather than always dispatching the closest medical units, could improve the effectiveness …

Predicting Surgical Flow Disruption Recovery In Cardiothoracic Operating Rooms, Gary Palmer Ii

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Disruptions are common occurrences in a variety of healthcare settings and early research has shown that they are likely contributors to medical errors. For this reason, healthcare researchers have focused on studying and understanding the nature of Surgical Flow Disruptions (SFDs) to increase patient safety and quality of care within the operating room (OR). Many researchers have used simplistic taxonomies to collect and categorize the types of SFD that occur within the OR. Others have gone further to study SFD recovery and have link unrecovered and recovered SFD to minor and major adverse events experienced by patients. This dissertation, focused …

Characteristics And Contributing Factors Of Emergency Vehicle Crashes, Naji Abdelwanis

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The purpose of this study is to determine the contributing factors and characteristics associated with emergency vehicle(EV) crashes in order to generate insights about the emergency crashes. This dissertation consists of three approaches to address the purpose. In the first analysis a binary logistic regression model was used to identify the critical factors associated with EV crashes that resulted in fatality compared to those that did not. In the second analysis, an ordered regression model was used to identify critical factors that contributed to the severity of injuries that EV occupants experience in crashes as well as the effect of …

Joint Location And Dispatching Decisions For Emergency Medical Service Systems, Hector Toro-Diaz

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Emergency Medical Service (EMS) systems are a service that provides acute care and transportation to a place for definitive care, to people experiencing a medical emergency. The ultimate goal of EMS systems is to save lives. The ability of EMS systems to do this effectively is impacted by several resource allocation decisions including location of servers (ambulances), districting of demand zones and dispatching rules for the servers. The location decision is strategic while the dispatching decision is operational. Those two decisions are usually made separately although both affect typical EMS performance measures. The service from an ambulance is usually time …

Evolution Of Medication Administration Workflow In Implementing Electronic Health Record System, Yuan-Han Huang

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This study focused on the clinical workflow evolutions when implementing the health information technology (HIT). The study especially emphasized on administrating medication when the electronic health record (EHR) systems were adopted at rural healthcare facilities. Mixed-mode research methods, such as survey, observation, and focus group, were used to investigate insightful interventions to compensate potential errors during the medication administration process. Research data were collected from three South Carolina small-scale rural hospitals over several clinical departments.
The major purposes of this study were two folds: (1) to assess medical staff's computer competency for the new IT system, and (2) to investigate …

Robust Parameter Design In Complex Engineering Systems:, Gregory Boylan

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Many industrial firms seek the systematic reduction of variability as a primary means for reducing production cost and material waste without sacrificing product quality or process efficiency. Despite notable advancements in quality-based estimation and optimization approaches aimed at achieving this goal, various gaps remain between current methodologies and observed in modern industrial environments. In many cases, models rely on assumptions that either limit their usefulness or diminish the reliability of the estimated results. This includes instances where models are generalized to a specific set of assumed process conditions, which constrains their applicability against a wider array of industrial problems. However, …

Integrated Production And Distribution Problem With Single Perishable Product, Wennian Li

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This dissertation investigated the extension of the Integrated Production and Distribution Scheduling Problem (IPDSPP) using a variety of perishable products, applying the JIP principle and make-to-order strategy to integrate the production and distribution schedules. A single perishable product with a constant lifetime after production was used in the model discussed here. The objective of the problem was to find the solution that results in minimal system total transportation costs while satisfying customer demand within a fixed time horizon. In the solution, the fleet size, vehicle route and distribution schedule, plant production batch size and schedule were determined simultaneously. This research …

Supply Chain Network Design: Risk-Averse Vs. Risk-Neutral Decision Making, Alireza Madadi

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Recent events, such as the Heparin tragedy, highlight the necessity for designers and planners of supply chain networks to consider the risk of disruptions in spite of their low probability of occurrence. One effective way to hedge against supply chain network disruptions is to have a robustly designed supply chain network. This involves strategic decisions, such as choosing which markets to serve, which suppliers to source from, the location of plants, the types of facilities to use, and tactical decisions, such as production and capacity allocation. In this dissertation, we focus on models for designing supply chain networks that are …

A Process Analysis Of Engineering Problem Solving And Assessment Of Problem Solving Skills, Sarah Grigg

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In the engineering profession, one of the most critical skills to possess is accurate and efficient problem solving. Thus, engineering educators should strive to help students develop skills needed to become competent problem solvers. In order to measure the development of skills, it is necessary to assess student performance, identify any deficiencies present in problem solving attempts, and identify trends in performance over time. Through iterative assessment using standard assessment metrics, researchers/instructors are able to track trends in problem solving performance across time, which can serve as a gauge of students' learning gains.
This research endeavor studies the problem solving …

A Comprehensive Human Factors Analysis Of Off-Duty Motor Vehicle Crashes In The United States Military, Rebecca Iden

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Researchers have always had great interest in traffic safety and the phenomenon of motor vehicle crashes (MVCs). Though scores of service members are severely injured or killed in off-duty MVCs each year, few studies have addressed the MVC phenomenon within the military population and none have conducted a comprehensive evaluation of the causal factors associated with MVCs involving military personnel.
The main purpose of this dissertation was to gain a greater understanding of the causal factors associated with serious and fatal off-duty personal MVCs for military service members with the ultimate goal of preventing future losses. The HFACS-MVC framework was …

Research And Development Effort In Developing The Optimal Formulations For New Tablet Drugs, Zhe Li

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Seeking the optimal pharmaceutical formulation is considered one of the most critical research components during the drug development stage. It is also an R&D effort incorporating design of experiments and optimization techniques, prior to scaling up a manufacturing process, to determine the optimal settings of ingredients so that the desirable performance of related pharmaceutical quality characteristics (QCs) specified by the Food and Drug Administration (FDA) can be achieved. It is widely believed that process scale-up potentially results in changes in ingredients and other pharmaceutical manufacturing aspects, including site, equipment, batch size and process, with the purpose of satisfying the clinical …

Extending Origami Technique To Fold Forming Of Sheet Metal Products, Ala Qattawi

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This dissertation presents a scientific based approach for the analysis of folded sheet metal products. Such analysis initializes the examination in terms of topological exploration using set of graph modeling and traversal algorithms. The geometrical validity and optimization are followed by utilizing boundary representation and overlapping detection during a geometrical analysis stage, in this phase the optimization metrics are established to evaluate the unfolded sheet metal design in terms of its manufacturability and cost parameters, such as nesting efficiency, total welding cost, bend lines orientation, and maximum part extent, which aides in handling purposes. The proposed approach evaluates the design …

Metaheuristics For Hub Location Models, Ornurai Sangsawang

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In this research, we propose metaheuristics for solving two p-hub median problems.. The first p-hub median problem, which is NP-hard, is the uncapacitated single p-hub median problem (USApHMP). In this problem, metaheuristics such as genetic algorithms, simulated annealing and tabu search, are applied in different types of representations. Caching is also
applied to speed up computational time of the algorithms. The results clearly demonstrate that tabu search with a permutation solution representation, augmented with caching is the highest performing method, both in terms of solution quality and computational time among these algorithms for the USApHMP. We also investigate the performance …

Anticipating U.S. Population-Level Health And Economic Impacts Using Discrete-Event Simulation To Guide Health Policy Decisions, Odette Reifsnider

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This dissertation presents two applications of discrete-event simulation (DES) to represent clinical processes: (1) a model to quantify the risk of the maternal obese and diabetic intrauterine environment influence on progression to adult obesity and diabetes, and (2) a model to evaluate health and economic outcomes of different smoking cessation strategies. The first application considers the public health impact of the diabetic and obese intrauterine environment's effect on the prevalence of diabetes and obesity across subsequent generations. We first develop a preliminary DES model to investigate and characterize the epidemiology of diabetes during pregnancy and birth outcomes related to maternal …

The Effects Of Weather Recognition Training On General Aviation Pilot Situation Assessment And Tactical Decision Making When Confronted With Adverse Weather Conditions, Chansik Kim

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Previous general aviation (GA) accident studies showed that decision errors were more associated with fatal GA accidents than other kinds of human errors, and weather related accidents, especially continued visual flight rules (VFR) flight into instrument meteorological conditions (IMC), remained the major cause of fatal GA accidents. Thus, finding the underlying causes of GA pilots' decision errors and continued VFR flight into adverse weather conditions are needed to reduce weather related GA accidents as well as fatal GA accidents.
Causal factors and hypotheses of weather related GA accidents show that knowledge, experience, motivation, and weather information frequently have been referred …

Improving Quality Of Service In Ems Systems By Reducing Disparities Between Service Zones, Sunarin Chanta

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Emergency medical service (EMS) systems respond to emergency or urgent calls so as to provide immediate care, such as pre-hospital care and/or transportation, to hospitals. Care must be provided in a timely manner; in fact quality of service is usually directly associated with response time. To reduce the response time, the number and location of vehicles within the service area are important variables. However with limited capacity, increasing the number of vehicles is often an infeasible alternative. Therefore, a critical design goal is to decide at which facilities stations should be located in order to serve as much demand as …