Nanoscience and Nanotechnology Commons^™

Toxicity Of Cdse Nanoparticles In Caco-2 Cell Cultures, Lin Wang, Dattatri K. Nagesha, Selvapraba Selvarasah, Mehmet R. Dokmeci, Rebecca L. Carrier

Dattatri K. Nagesha

BackgroundPotential routes of nanomaterial exposure include inhalation, dermal contact, and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied; however, risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model, the possible toxicity of CdSe quantum dot (QD) exposure via ingestion was investigated. Effect of simulated gastric fluid treatment on CdSe QD cytotoxicity was also studied. ResultsCommercially available CdSe QDs, which have a ZnS shell and poly-ethylene glycol (PEG) coating, and in-house prepared surfactant coated CdSe QDs were dosed to Caco-2 cells. Cell viability and attachment were studied …

Toxicity Of Cdse Nanoparticles In Caco-2 Cell Cultures, Lin Wang, Dattatri K. Nagesha, Selvapraba Selvarasah, Mehmet R. Dokmeci, Rebecca L. Carrier

Rebecca L. Carrier

BackgroundPotential routes of nanomaterial exposure include inhalation, dermal contact, and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied; however, risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model, the possible toxicity of CdSe quantum dot (QD) exposure via ingestion was investigated. Effect of simulated gastric fluid treatment on CdSe QD cytotoxicity was also studied. ResultsCommercially available CdSe QDs, which have a ZnS shell and poly-ethylene glycol (PEG) coating, and in-house prepared surfactant coated CdSe QDs were dosed to Caco-2 cells. Cell viability and attachment were studied …

Toxicity Of Cdse Nanoparticles In Caco-2 Cell Cultures, Lin Wang, Dattatri Nagesha, Selvapraba Selvarasah, Mehmet Dokmeci, Rebecca Carrier

Mehmet R. Dokmeci

Background
Potential routes of nanomaterial exposure include inhalation, dermal contact, and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied; however, risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model, the possible toxicity of CdSe quantum dot (QD) exposure via ingestion was investigated. Effect of simulated gastric fluid treatment on CdSe QD cytotoxicity was also studied.

Results
Commercially available CdSe QDs, which have a ZnS shell and poly-ethylene glycol (PEG) coating, and in-house prepared surfactant coated CdSe QDs were dosed to Caco-2 cells. Cell viability and attachment …