Biomedical Commons^™

An Automated, Deep Learning Approach To Systematically & Sequentially Derive Three-Dimensional Knee Kinematics Directly From Two-Dimensional Fluoroscopic Video, Viet Dung Nguyen

Doctoral Dissertations

Total knee arthroplasty (TKA), also known as total knee replacement, is a surgical procedure to replace damaged parts of the knee joint with artificial components. It aims to relieve pain and improve knee function. TKA can improve knee kinematics and reduce pain, but it may also cause altered joint mechanics and complications. Proper patient selection, implant design, and surgical technique are important for successful outcomes. Kinematics analysis plays a vital role in TKA by evaluating knee joint movement and mechanics. It helps assess surgery success, guides implant and technique selection, informs implant design improvements, detects problems early, and improves patient …

A Rapid And Ultra-Sensitive Biosensing Platform Based On Tunable Dielectrophoresis For Robust Poc Applications, Yu Jiang

Doctoral Dissertations

With the ongoing pandemic, there have been increasing concerns recently regarding major public health issues such as abuse of organophosphorus compounds, pathogenic bacterial infections, and biosecurity in agricultural production. Biosensors have long been considered a kernel technology for next-generation diagnostic solutions to improve food safety and public health. Significant amounts of effort have been devoted to inventing novel sensing mechanisms, modifying their designs, improving their performance, and extending their application scopes. However, the reliability and selectivity of most biosensors still have much to be desired, which holds back the development and commercialization of biosensors, especially for on-site and point-of-care (POC) …

A Bulk Driven Transimpedance Cmos Amplifier For Sipm Based Detection, Shahram Hatefi Hesari

Masters Theses

The contribution of this work lies in the development of a bulk driven operational
transconducctance amplifier which can be integrated with other analog circuits and
photodetectors in the same chip for compactness, miniaturization and reducing the
power. Silicon photomultipliers, also known as SiPMs, when coupled with scintillator materials are used in many imaging applications including nuclear detection. This thesis discuss the design of a bulk-driven transimpedance amplifier suitable for detectors where the front end is a SiPM. The amplifier was design and fabricated in a standard standard CMOS process and is suitable for integration with CMOS based SiPMs and commercially …

The Bracelet: An American Sign Language (Asl) Interpreting Wearable Device, Samuel Aba, Ahmadre Darrisaw, Pei Lin, Thomas Leonard

Chancellor’s Honors Program Projects

No abstract provided.

Non-Contact Techniques For Human Vital Sign Detection And Gait Analysis, Farnaz Foroughian

Doctoral Dissertations

Human vital signs including respiratory rate, heart rate, oxygen saturation, blood pressure, and body temperature are important physiological parameters that are used to track and monitor human health condition. Another important biological parameter of human health is human gait. Human vital sign detection and gait investigations have been attracted many scientists and practitioners in various fields such as sport medicine, geriatric medicine, bio-mechanic and bio-medical engineering and has many biological and medical applications such as diagnosis of health issues and abnormalities, elderly care and health monitoring, athlete performance analysis, and treatment of joint problems. Thoroughly tracking and understanding the normal …

Design And Implementation Of An Isfet Sensor With Integration Of An On-Chip Processor, Shaghayegh Aslanzadeh

Doctoral Dissertations

Portable sensors are used in many applications. Among them, pH sensors are suitable for quantifying and identifying various analytes in real-time and doing so non-invasively. The analytes may have environmental impact such as in water quality monitoring. The analytes may also have biological impact such as monitoring cell culture or remote patient health assessment. CMOS based sensors are compact and enable low power consumption suitable for these portable applications.

This work reports on the development of a portable CMOS based pH sensor. The contributions of this dissertation are as follows. First, a differential pH sensor, with two different sized electrodes …

Camera-Based Remote Photoplethysmography For Estimation Of Heart Rate Using Single Board Computers, Benjamin Sweely

Masters Theses

The objective of this project was to develop a wireless, noncontact monitoring system that measures multiple physiological parameters in human faces from a distance using a camera. Compared to traditional sensors, this monitoring system does not use wires or adhesives, providing a safer, more user-friendly application. The goal of the monitoring systems was to estimate heart rate (HR). The current practices of measuring HR involve collecting electrocardiogram (ECG) signals from adhesive electrodes placed on various parts of the body and using a pulse oximeter (PO) typically placed on the ear lobe or finger. We were able to successfully create 2 …

Design And Implementation Of A Low‐Power Wireless Respiration Monitoring Sensor, Ifana Mahbub

Doctoral Dissertations

Wireless devices for monitoring of respiration activities can play a major role in advancing modern home-based health care applications. Existing methods for respiration monitoring require special algorithms and high precision filters to eliminate noise and other motion artifacts. These necessitate additional power consuming circuitry for further signal conditioning. This dissertation is particularly focused on a novel approach of respiration monitoring based on a PVDF-based pyroelectric transducer. Low-power, low-noise, and fully integrated charge amplifiers are designed to serve as the front-end amplifier of the sensor to efficiently convert the charge generated by the transducer into a proportional voltage signal. To transmit …

Development Of A Low Cost Biosensing Platform For Highly Sensitive And Specific On-Site Detection Of Pathogens And Infections, Cheng Cheng

Doctoral Dissertations

A highly sensitive, specific, real time, and field-deployable surveillance tool is critical to the control of pathogens and infections, as well as ecological impact of chemicals exposure. This work investigates the development of a low cost biosensing platform that can be used for viral disease diagnosis and chemical detection. The sensing mechanism is known as AC electrokinetics (ACEK) capacitive sensing. By applying an inhomogeneous AC electric field on sensor electrodes, positive dielectrophoresis is induced to accelerate the travel of analytes. The same applied AC signal also directly measures the capture of target by the probe on sensor surface. The realized …

The Design And Validation Of A Wireless Bat-Mounted Sonar Recording System, Jeremy Joseph Langford

Masters Theses

Scientists studying the behavior of bats monitor their echolocation calls, as their calls are important for navigation and feeding, but scientist are typically restricted to ground-based recording. Recording bat calls used for echolocation from the back of the bat as opposed to the ground offers the opportunity to study bat echolocation from a vantage otherwise only offered to the bats themselves. However, designing a bat mounted in-flight audio recording system, (bat-tag), capable of recording the ultra-sound used in bat echolocation presents a unique set of challenges. Chiefly, the bat-tag must be sufficiently light weight as to not overburden the bat, …

Adaptive Kernel Estimation For Enhanced Filtering And Pattern Classification Of Magnetic Resonance Imaging: Novel Techniques For Evaluating The Biomechanics And Pathologic Conditions Of The Lumbar Spine, Nicholas Vincent Battaglia

Doctoral Dissertations

This dissertation investigates the contribution the lumbar spine musculature has on etiological and pathogenic characteristics of low back pain and lumbar spondylosis. This endeavor necessarily required a two-step process: 1) design of an accurate post-processing method for extracting relevant information via magnetic resonance images and 2) determine pathological trends by elucidating high-dimensional datasets through multivariate pattern classification. The lumbar musculature was initially evaluated by post-processing and segmentation of magnetic resonance (MR) images of the lumbar spine, which characteristically suffer from nonlinear corruption of the signal intensity. This so called intensity inhomogeneity degrades the efficacy of traditional intensity-based segmentation algorithms. Proposed …

Design And Implementation Of An Integrated Biosensor Platform For Lab-On-A-Chip Diabetic Care Systems, Khandaker Abdullah Al Mamun

Doctoral Dissertations

Recent advances in semiconductor processing and microfabrication techniques allow the implementation of complex microstructures in a single platform or lab on chip. These devices require fewer samples, allow lightweight implementation, and offer high sensitivities. However, the use of these microstructures place stringent performance constraints on sensor readout architecture. In glucose sensing for diabetic patients, portable handheld devices are common, and have demonstrated significant performance improvement over the last decade. Fluctuations in glucose levels with patient physiological conditions are highly unpredictable and glucose monitors often require complex control algorithms along with dynamic physiological data. Recent research has focused on long term …

Alternating Current Electrokinetics Based Capacitive Affinity Biosensor: A Point-Of-Care Diagnostic Platform, Haochen Cui

Doctoral Dissertations

Capacitive bioaffinity detection using microelectrodes is considered as a promising label-free method for point-of-care diagnosis, though with challenges in sensitivity, specificity and the time “from sample to result.” This work presents an alternating current (AC)-electrokinetic based capacitive affinity sensing method that is capable of realizing rapid in-situ detection of specific biomolecular interactions such as probe-analyte binding. The capacitive biosensor presented here employs elevated AC potentials at a fixed frequency for impedimetric interrogation of the microelectrodes. Such an AC signal is capable of inducing dielectrophoresis (DEP) and AC electrothermal (ACET) effects, so as to realize in-situ enrichment of macro and even …

A Magnetic Actuated Fully Insertable Robotic Camera System For Single Incision Laparoscopic Surgery, Xiaolong Liu

Doctoral Dissertations

Minimally Invasive Surgery (MIS) is a common surgical procedure which makes tiny incisions in the patients anatomy, inserting surgical instruments and using laparoscopic cameras to guide the procedure. Compared with traditional open surgery, MIS allows surgeons to perform complex surgeries with reduced trauma to the muscles and soft tissues, less intraoperative hemorrhaging and postoperative pain, and faster recovery time. Surgeons rely heavily on laparoscopic cameras for hand-eye coordination and control during a procedure. However, the use of a standard laparoscopic camera, achieved by pushing long sticks into a dedicated small opening, involves multiple incisions for the surgical instruments. Recently, single …

Wide Band Embedded Slot Antennas For Biomedical, Harsh Environment, And Rescue Applications, Yun Seo Koo

Doctoral Dissertations

For many designers, embedded antenna design is a very challenging task when designing embedded systems. Designing Antennas to given set of specifications is typically tailored to efficiently radiate the energy to free space with a certain radiation pattern and operating frequency range, but its design becomes even harder when embedded in multi-layer environment, being conformal to a surface, or matched to a wide range of loads (environments).

In an effort to clarify the design process, we took a closer look at the key considerations for designing an embedded antenna. The design could be geared towards wireless/mobile platforms, wearable antennas, or …

A Low-Power Approach For Front End Biological Signal Conditioning, Logan Smith Taylor

Masters Theses

In a lab-on-a-chip (LOC) application, the measurement of small analog signals such as local temperature variation often involves detection of very low-level signals in a noisy micro-scale environment. This is true for other biomedical monitoring systems as well. These systems observe various physiological parameters or electrochemical reactions that need to be tracked electrically. For temperature measurement pyroelectric transducers represent an efficient solution in terms of speed, sensitivity, and scale of integration, especially when prompt and accurate temperature monitoring is desired.

The ability to perform laboratory operations on a small scale using miniaturized LOC devices is a promising biosensing technique. The …

In-Line Microfluidic Particle Preconcentrator And Detector For Continuous Flow Monitoring, Quan Yuan

Doctoral Dissertations

This dissertation presents the design and prototyping of three in-line microfluidic devices for continuous monitoring of particulate flows. The three devices are AC electrokinetic (ACEK) and acoustic sample preconcentration techniques for resettable particle enrichment, and an in-line somatic cell counter for mastitis monitoring.

For the ACEK preconcentrator, ACEK is a new and promising technique to manipulate micro/bio-fluid and particles. There are many advantages over other techniques, such as low applied voltage, low cost, portability and notable biocompatibility of lab-on-a-chip (LOC) device. We successfully developed a 3D multi-level electrode platform to extract bioparticles via AC electroosmosis (ACEO) and negative Dielectrophoresis (DEP). …

Improved Forensic Medical Device Security Through Eating Detection, Nathan Lee Henry

Masters Theses

Patients are increasingly reliant on implantable medical device systems today. For patients with diabetes, an implantable insulin pump system or artificial pancreas can greatly improve quality of life. As with any device, these devices can and do suffer from software and hardware issues, often reported as a safety event. For a forensic investigator, a safety event is indistinguishable from a potential security event. In this thesis, we show a new sensor system that can be transparently integrated into existing and future electronic diabetes therapy systems while providing additional forensic data to help distinguish between safety and security events. We demonstrate …

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Doctoral Dissertations

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from …

Reconstruction Of Patient-Specific Bone Models From X-Ray Radiography, Hatem Amin Abdel Fattah El Dakhakhni

Doctoral Dissertations

The availability of a patient‐specific bone model has become an increasingly invaluable addition to orthopedic case evaluation and planning [1]. Utilized within a wide range of specialized visualization and analysis tools, such models provide unprecedented wealth of bone shape information previously unattainable using traditional radiographic imaging [2]. In this work, a novel bone reconstruction method from two or more x‐ray images is described. This method is superior to previous attempts in terms of accuracy and repeatability. The new technique accurately models the radiological scene in a way that eliminates the need for expensive multi‐planar radiographic imaging systems. It is also …

An Implantable Low Pressure Biosensor Transponder, Chad Eric Seaver

Masters Theses

The human body’s intracranial pressure (ICP) is a critical element in sustaining healthy blood flow to the brain while allowing adequate volume for brain tissue within the relatively rigid structure of the cranium. Disruptions in the body’s maintenance of intracranial pressure are often caused by hemorrhage, tumors, edema, or excess cerebral spinal fluid resulting in treatments that are estimated to globally cost up to approximately five billion dollars annually. A critical element in the contemporary management of acute head injury, intracranial hemorrhage, stroke, or other conditions resulting in intracranial hypertension, is the real-time monitoring of ICP. Currently such monitoring can …

A Low-Power, Highly Stabilized Three-Electrode Potentiostat Using Subthreshold Techniques, Melika Roknsharifi

Doctoral Dissertations

Implantable micro- and nano- sensors and implantable microdevices (IMDs) have demonstrated potential for monitoring various physiological parameters such as glucose, lactate, CO₂ [carbon dioxide], pH, etc. Potentiostats are essential components of electrochemical sensors such as glucose monitoring devices for diabetic patients. Diabetes is a metabolic disorder associated with insufficient production or inefficient utilization of insulin. The most important role of this enzyme is to regulate the metabolic breakdown of glucose generating the necessary energy for human activities. Diabetic patients typically monitor their blood glucose levels by pricking a fingertip with a lancing device and applying the blood to a …

Development And Experimental Analysis Of Wireless High Accuracy Ultra-Wideband Localization Systems For Indoor Medical Applications, Michael Joseph Kuhn

Doctoral Dissertations

This dissertation addresses several interesting and relevant problems in the field of wireless technologies applied to medical applications and specifically problems related to ultra-wideband high accuracy localization for use in the operating room. This research is cross disciplinary in nature and fundamentally builds upon microwave engineering, software engineering, systems engineering, and biomedical engineering. A good portion of this work has been published in peer reviewed microwave engineering and biomedical engineering conferences and journals. Wireless technologies in medicine are discussed with focus on ultra-wideband positioning in orthopedic surgical navigation. Characterization of the operating room as a medium for ultra-wideband signal transmission …

In Situ Preconcentration By Ac Electrokinetics For Rapid And Sensitive Nanoparticle Detection, Kai Yang

Doctoral Dissertations

Reducing cost and time is a major concern in clinical diagnostics. Current molecular diagnostics are multi-step processes that usually take at least several hours or even days to complete multiple reagents delivery, incubations and several washing processes. This highly labor-intensive work and lack of automation could result in reduced reliability and low efficiency. The Laboratory-on-a-chip (LOC), taking advantage of the merger and development of microfluidics and biosensor technology, has shown promise towards a solution for performing analytical tests in a self-contained and compact unit, enabling earlier and decentralized testing. However, challenges are to integrate the fluid regulatory elements on a …

Classification System For Impedance Spectra, Carl Gordon Sapp

Masters Theses

This thesis documents research, methods, and results to satisfy the requirements for the M.S. degree in Electrical Engineering at the University of Tennessee. This thesis explores two primary steps for proper classification of impedance spectra: data dimension reduction and effectiveness of similarity/dissimilarity measure comparison in classification. To understand the data characteristics and classification thresholds, a circuit model analysis for simulation and unclassifiable determination is studied. The research is conducted using previously collected data of complex valued impedance measurements taken from 1844 similar devices. The results show a classification system capable of proper classification of 99% of data samples with well-separated …

Optimization Of Alternating Current Electrothermal Micropump By Numerical Simulation, Quan Yuan

Masters Theses

Microfluidic technology has been grown rapidly in the past decade. Microfluidics can find wide applications in multiple fields such as medicine, electronics, chemical and biology. Micro-pumping is an essential part of a microfluidic system. This thesis presents the optimization process of AC electro-thermal micropump with respect to the geometry of electrode array and channel height.

The thesis first introduces the theories of AC electrokinetic including dielectrophoresis, AC electro-osmosis (ACEO) and AC electro-thermal (ACET). Also presented are the basic theory and governing equations of microfluidics, the continuity equation, the Navier-Stokes equation, and the conservation of energy equation. AC electro-thermal effect results …