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Full-Text Articles in Biomedical Engineering and Bioengineering
Pharmacokinetic Modeling Of 99mtc-Hmpao Images Of Isolated Perfused Rat Lungs, Katherine C. Barry
Pharmacokinetic Modeling Of 99mtc-Hmpao Images Of Isolated Perfused Rat Lungs, Katherine C. Barry
Master's Theses (2009 -)
The single-photon emission tomography (SPECT) imaging biomarker technetium-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) exists in two forms, the oxidized, cell-permeable form and the reduced, cell-impermeable form. Recent studies revealed that the lung uptake of 99mTc-HMPAO increases early in rat models of human acute lung injury. Lung uptake of 99mTc-HMPAO is the net result of multiple cellular and vascular processes, many of which can vary with acute illness. Thus, when a change in the lung uptake of 99mTc-HMPAO is detected, it is unclear how much of this change is due to alteration in the activity of the targeted cellular process versus alteration of …
Development And Performance Of A Sparsity-Exploiting Algorithm For Few-View Single Photon Emission Computed Tomogrpahy (Spect) Reconstruction, Paul Arthur Wolf
Development And Performance Of A Sparsity-Exploiting Algorithm For Few-View Single Photon Emission Computed Tomogrpahy (Spect) Reconstruction, Paul Arthur Wolf
Master's Theses (2009 -)
Single Photon Emission Computed Tomography (SPECT) provides noninvasive images of the distribution of radiotracer molecules. Dynamic Single Photon Emission Computed Tomography provides information about tracer uptake and washout from a series of time-sequence images. Stationary ring-like multi-camera systems are being developed to provide rapid dynamic acquisitions with high temporal sampling. Reducing the number of cameras reduces the cost of such systems but also reduces the number of views acquired, limiting the angular sampling of the system. Novel few-view image reconstruction methods may be beneficial and are being investigated for the application of dynamic SPECT. A sparsity-exploiting algorithm intended for few-view …