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Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon
Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon
Theses and Dissertations
Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled proliferation of long-lived plasma cells (PCs) in the bone marrow (BM), which constitute at least 10% of BM cellularity. Normally, long-lived plasma cells make up less than 1% of BM cells. Plasma cells become neoplastic when a clonal PC population produces a monoclonal immunoglobulin protein. A diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is made when there is an increase in monoclonal PCs within the BM, but less than 10%, and the patient does not present with end-organ damage, which is associated with active MM. Though not considered …
Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon
Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon
Theses and Dissertations
Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled proliferation of long-lived plasma cells (PCs) in the bone marrow (BM), which constitute at least 10% of BM cellularity. Normally, long-lived plasma cells make up less than 1% of BM cells. Plasma cells become neoplastic when a clonal PC population produces a monoclonal immunoglobulin protein. A diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is made when there is an increase in monoclonal PCs within the BM, but less than 10%, and the patient does not present with end-organ damage, which is associated with active MM. Though not considered …